… of SUMO pathway inhibition in cancer patients. In this comprehensive review, we critically
discuss the potential of targeting the SUMO pathway as a therapeutic option for cancer. …

… Recent evidence indicated that inhibiting the SUMO pathway repressed tumor growth and …
mechanism has yet to be clarified. Here, we demonstrate that inhibition of the SUMO pathway …

… of the SUMO pathway in PDAC. We will describe the known functions of the SUMO pathway
in … We will explain how the SUMO pathway is connected to the MYC oncogene and how this …

… Table 1 SUMO pathway components … This Review discusses the mechanisms of SUMO
conjugation to proteins … Mechanistically, inhibition of transcription factors by sumoylation can be …

… However, the latter could be reactivated by pro-oxidants or by inhibition of the SUMO
pathway using either a pharmacological inhibitor of SUMOylation (anacardic acid) or RNA …

… )ylation and blocking SUMOylation consequently inhibits cell … activating triggers, therefore
inhibition of SUMOylation has the … In recent years, novel SUMO pathway inhibitors have been …

… between both pathways. We demonstrate the relevance of the SUMO pathway as a therapeutic
target by the use of novel SUMO-activating enzyme subunit pathway inhibitors and show …

… SUMO conjugation pathway … mechanisms of action. Certain compounds disclosed in this
review have also been reported in other articles for their inhibition of the SUMOylation pathway …

… for the development of inhibitors targeting other Ubl pathways. … mechanism by which
COH000 inhibits SUMO E1 activity, we determined crystal structures of SUMO E1 alone (SUMO E1 …

… SUMO-unconjugated TFAP2A. We sought to evaluate effects of inhibiting the SUMO pathway
… We conclude that inhibition of the SUMO pathway repressed the CSC population, delaying …