… VEGFR2 homodimer signalling is modulated by different VEGF-binding co-receptors, …
the integrins, particularly integrin-β1 and integrin-β3. Note that sequence motifs for VEGF–integrin …

… between VEGF co-receptors, HSPGs, and integrin switching … We hypothesized that VEGF
binding to the ECM is modulated … VEGF matrix binding and the engagement of β1 integrins are …

… the angiogenic response. Binding of VEGF to VEGFR2 in cooperation with integrin signaling
… , motility, and proliferation, processes critical for the angiogenic response. There are several …

… These conformational changes in the extracellular domains of integrins modulate both …
VEGF-A or fibroblast growth factor-2. Integrin α V β 3 works synergistically with VEGF to activate …

… lesson from past integrin drug … integrin-regulatory mechanisms and unmet clinical needs.
Herein, we provide a systematic and complete review of all integrin family members and integrin…

… integrin/VEGF signalling which is highly effective for vascularization events in vitro with low
concentrations of VEGF… via combined integrin/VEGF signalling. In vivo experiments using 3D …

… that modulation of integrins, for example by varying matrix stiffness or integrin-modulating …
VEGFR2 association with β1 integrins promotes signaling induced by matrix-bound VEGF, …

… modulate an affinity of integrins for their extracellular ligands [17]. Formation of … -integrin
complexes on endothelial cells promotes VEGF-dependent neovascularization [91]. Activation of …

… role that RGD-binding integrins can have in complex multifactorial retinal … integrins can
modulate the intricate molecular pathways and regulate the underlying pathological mechanisms…

… , resulting in a suitable cellular response. However, it is yet … pathways are activated and
interact with integrins to regulate … cells, high VEGF signaling activates the expression of the …