… helical initiation and termination domains H1, 1A and 2B (4, 5). … Ogden, Dundee, UK) directed
against keratin 5 of lesional skin … Staining was positive in the blister roof and floor. Staining …

… common subtype and results in blistering within or above the … helix initiation peptide, HIP)
and 2B (helix termination peptide, … mutational “hot spots” in most hereditary keratin disorders.7 …

… a group of hereditary disorders, in which blisters occur … keratin 5 and keratin 14 have a
central rod-like alpha helix … initiation peptide (HIP) and helix termination peptide (HTP) 9 . …

… an inherited mechanobullous disease resulting in blistering … common subtype and results
in blistering within or above the … helix initiation peptide, HIP) and 2B (helix termination peptide, …

… Mutations in keratins 5/14 or in other genes that encode … include skin fragility, with general
or localized blistering in … of the helix initiation and helix termination peptides and in the …

… mutations in the genes encoding keratin 5 and keratin 14 (… and mutations in these regions
often result in severe blistering, … initiation (HIP) and termination peptides (HTP) regions, …

… Other disorders with skin fragility, where blisters are a minor … acid within the keratin polypeptide
determines the severity of … or termination motifs impair heterodimerization of keratin 5 and …

… by mechanical stress-induced blistering of the skin (1). EBS … keratin 5 (KRT5) and 2B
domain of KRT14, also known as helix initiation peptide (HIP) and helix termination peptide …

… These linker peptides are denoted as LI, L I2, and L2 and … termination motif at the end of the
2B segment (Figure 5). … , thus preventing cell lysis and blister formation and other secondary …

… Recently, a new clinical-genetic classification of the inherited … initiation peptide" (HIP) and
"helix termination peptide" (HTP)… Blisters were absent, a feature supported by the absence of …