Epidermal growth factor receptor cell proliferation signaling pathways

P Wee, Z Wang - Cancers, 2017 - mdpi.com
… The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is commonly
upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer, …

The epidermal growth factor network: role in oocyte growth, maturation and developmental competence

D Richani, RB Gilchrist - Human reproduction update, 2018 - academic.oup.com
… Likewise, this event represents a major milestone in the oocyte… BTC activate the epidermal
growth factor receptor (EGFR) (… Ligand availability does not solely account for the increased …

Molecular basis for multimerization in the activation of the epidermal growth factor receptor

Y Huang, S Bharill, D Karandur, SM Peterson, M Marita… - elife, 2016 - elifesciences.org
… We subtracted this baseline fraction of two-step bleaching events from all the data shown
in … effects on the receptor dimerization, as noted earlier, which might account for the neutral …

Temporal perturbation of ERK dynamics reveals network architecture of FGF2/MAPK signaling

Y Blum, J Mikelson, M Dobrzyński, H Ryu… - Molecular systems …, 2019 - embopress.org
… A mathematical model that accounts for these responses is … Plain black arrows indicate fast
binding/unbinding events. … signalling patterns from the fibroblast growth factor receptor. Cell …

Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies

Z An, O Aksoy, T Zheng, QW Fan, WA Weiss - Oncogene, 2018 - nature.com
… through dimerization with human epidermal growth factor receptor 3, or through … signaling
[36]. A recent study indicates that loss of chromosome 10q (including PTEN) is an early event

Epidermal growth factor receptor in glioblastoma

H Xu, H Zong, C Ma, X Ming, M Shang… - Oncology …, 2017 - spandidos-publications.com
… In addition to overexpression, several alternative mechanisms account for aberrant … tumors,
supporting the notion that deregulated EGFR expression and signaling are pivotal events in …

The extracellular matrix as a key regulator of intracellular signalling networks

JF Hastings, JN Skhinas, D Fey… - British journal of …, 2019 - Wiley Online Library
… mathematical models to describe the signalling events that cannot … components that takes
into account known mechanisms of … of constant stimulation by growth factors, cytokines, ECM …

Modeling cell line-specific recruitment of signaling proteins to the insulin-like growth factor 1 receptor

KE Erickson, OS Rukhlenko… - PLoS computational …, 2019 - journals.plos.org
growth factor 1 (IGF1) receptor (IGF1R), we formulated and analyzed 45 cell line-specific
mathematical models, which accountmodels as reasonable first approximations of early events

Effects of estrogen receptor and human epidermal growth factor receptor-2 levels on the efficacy of trastuzumab: a secondary analysis of the HERA trial

S Loi, U Dafni, D Karlis, V Polydoropoulou… - JAMA …, 2016 - jamanetwork.com
… day of follow-up if the corresponding event had not occurred. … crossover was not taken into
account and all patients were … potential importance of estrogen signaling for patients with …

Early clinical development of epidermal growth factor receptor targeted therapy in breast cancer

N Matsuda, B Lim, X Wang, NT Ueno - Expert opinion on …, 2017 - Taylor & Francis
… family, plays an important role in signal transduction pathways that regulate cellular function,
… On the other hand, it was identified that EGFR gene amplification was a rare event. One …