Epidermal growth factor receptor cell proliferation signaling pathways
… The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is commonly
upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer, …
upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer, …
The epidermal growth factor network: role in oocyte growth, maturation and developmental competence
D Richani, RB Gilchrist - Human reproduction update, 2018 - academic.oup.com
… Likewise, this event represents a major milestone in the oocyte… BTC activate the epidermal
growth factor receptor (EGFR) (… Ligand availability does not solely account for the increased …
growth factor receptor (EGFR) (… Ligand availability does not solely account for the increased …
Molecular basis for multimerization in the activation of the epidermal growth factor receptor
… We subtracted this baseline fraction of two-step bleaching events from all the data shown
in … effects on the receptor dimerization, as noted earlier, which might account for the neutral …
in … effects on the receptor dimerization, as noted earlier, which might account for the neutral …
Temporal perturbation of ERK dynamics reveals network architecture of FGF2/MAPK signaling
… A mathematical model that accounts for these responses is … Plain black arrows indicate fast
binding/unbinding events. … signalling patterns from the fibroblast growth factor receptor. Cell …
binding/unbinding events. … signalling patterns from the fibroblast growth factor receptor. Cell …
Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies
… through dimerization with human epidermal growth factor receptor 3, or through … signaling
[36]. A recent study indicates that loss of chromosome 10q (including PTEN) is an early event …
[36]. A recent study indicates that loss of chromosome 10q (including PTEN) is an early event …
Epidermal growth factor receptor in glioblastoma
H Xu, H Zong, C Ma, X Ming, M Shang… - Oncology …, 2017 - spandidos-publications.com
… In addition to overexpression, several alternative mechanisms account for aberrant … tumors,
supporting the notion that deregulated EGFR expression and signaling are pivotal events in …
supporting the notion that deregulated EGFR expression and signaling are pivotal events in …
The extracellular matrix as a key regulator of intracellular signalling networks
JF Hastings, JN Skhinas, D Fey… - British journal of …, 2019 - Wiley Online Library
… mathematical models to describe the signalling events that cannot … components that takes
into account known mechanisms of … of constant stimulation by growth factors, cytokines, ECM …
into account known mechanisms of … of constant stimulation by growth factors, cytokines, ECM …
Modeling cell line-specific recruitment of signaling proteins to the insulin-like growth factor 1 receptor
KE Erickson, OS Rukhlenko… - PLoS computational …, 2019 - journals.plos.org
… growth factor 1 (IGF1) receptor (IGF1R), we formulated and analyzed 45 cell line-specific
mathematical models, which account … models as reasonable first approximations of early events …
mathematical models, which account … models as reasonable first approximations of early events …
Effects of estrogen receptor and human epidermal growth factor receptor-2 levels on the efficacy of trastuzumab: a secondary analysis of the HERA trial
… day of follow-up if the corresponding event had not occurred. … crossover was not taken into
account and all patients were … potential importance of estrogen signaling for patients with …
account and all patients were … potential importance of estrogen signaling for patients with …
Early clinical development of epidermal growth factor receptor targeted therapy in breast cancer
… family, plays an important role in signal transduction pathways that regulate cellular function,
… On the other hand, it was identified that EGFR gene amplification was a rare event. One …
… On the other hand, it was identified that EGFR gene amplification was a rare event. One …