… -based anti-inflammatory compound used for the treatment of … focus mainly on its inhibitory
effects on antioxidant defensive … to the identification of a variety of targets for AUR, and this …

… Auranofin is an antiarthritic gold phosphine compound that … in contrast to other described
targets 103 . Therefore, future … mechanism of enzyme inhibition played by auranofin on GSTs…

… (GR), glutathione-S-transferase, 12 cysteine proteases, 13 … shown to be potently inhibited
by gold complexes. Interestingly, … and cell extracts, in comparison to auranofin, the gold(I) anti-…

… selectively targeted by Trx and GSH inhibitors. Trx and GSH … Conversely, the TrxR inhibitor
auranofin partially inhibits the … compounds, likely via S-nitrosylation (71, 72). Additionally, …

… represent a potential target for colorectal cancer therapy. … -NT substrate and Glutathione
S-Transferase) added to each well of … inhibitor auranofin and aldehyde dehydrogenase inhibitor …

… , cysteine protease, and glutathione-S-transferase, and therefore cause … However, auranofin,
a gold(I)-containing compound … Auranofin inhibited Clostridium difficile toxin production and …

… reference compounds (praziquantel, oxamniquine, auranofin … Schistosomal glutathione
s-transferase and sulfotransferase … In (D) yellow spheres are gold molecules from auranofin in …

… peroxidase, glutathione-S-transferase, … the inhibition of TrxR, a computational investigation
at DFT level analyzed the ligand exchange reactions of auranofin with the potential target …

… gold compounds [9], it was demonstrated that AUF targets … is an efficient TrxR inhibitor,
whereas such an inhibition of TrxR … synthetase (GSS) and glutathione S-transferase Mu 3 (GSTM3…

… cells, we co-targeted TrXR1 and multiple tyrosine kinases … the TrXR1 inhibitor Auranofin, a
gold compound FDA-… and apoptosis was associated with decreased glutathione-S-transferase…