… the use of gold-derived compounds [13] such as auranofin. … 1), while inducing alterations
in the glutathione-S-transferase (… with this compound revealed that 28 could also inhibit the …

… With this aim, we solved the crystal structure of gTrxR and we … 1), a glutathione S-transferase
non-peptide inhibitor and a … of auranofin has been solved, the mechanism of TrxR inhibition …

… the expression of its key target gene TR1, and increased the … that auranofin (AUR), a FoxO3
agonist and TR1 inhibitor, in … AUR, a gold-containing compound, has been widely used in …

… development, particularly glutathione S-transferase pi (GSTP) [201,… inhibitors, including gold-
or selenium-containing compounds… drugs, eg, the antirheumatic agent drug auranofin [221]. …

… metal inhibitors, auranofin (AF), a gold-containing compound… peroxidase 1 (GPX1), glutathione
S-transferase mu 1 (GSTM1)… molecules that target TrxR1 may not only inhibit the enzyme …

… were developed as potent inhibitors of seleno-enzymes. … I complex auranofin and the dinuclear
Au III compound Auoxo6 … reductase (GSR), glutathione S-transferase Mu 5 (GSTM5), but …

… metabolizing enzymes (eg, cytochromes and glutathione-S-transferase), elevated drug efflux
(… Similarly, inhibition of thioredoxin reductase by the gold(I) drug auranofin was proposed to …

… as a novel therapeutic target for several neurodegenerative … (KIM-1), alpha-glutathione
S-transferase (α-GST) and neutrophil … profile of auranofin, an oral gold-containing compound that …

… ROS homeostasis by inhibition of glutathione S-transferase and … Auranofin (AF) is a
well-characterized irreversible … with the aim of activating soluble guanylate cyclase and inhibiting …

… We have also shown that auranofin inhibits the growth of gastric cancer cells [49]. Interestingly,
this inhibition of gastric cancer … We have discovered that TrxR1 is a target of CTD. CTD …