Understanding the Role of Connexins in Hepatocellular Carcinoma: Molecular and Prognostic Implications

SP Papadakos, E Chatzikalil, K Arvanitakis… - Cancers, 2024 - mdpi.com
… activity and the enhancement of connexin expression via the … the presence of which marks
transcriptional activity and nuclear … fatty liver disease (NAFLD), is a chronic liver disease with a …

Connexin 32 and connexin 43 are involved in lineage restriction of hepatic progenitor cells to hepatocytes

H Pei, C Zhai, H Li, F Yan, J Qin, H Yuan… - Stem Cell Research & …, 2017 - Springer
… greatly enhanced during hepatocyte differentiation of WB cells … progenitor cells, we established
stable WB cell lines … potential in human hepatocellular carcinoma cells, which suggested …

[HTML][HTML] Role of connexin 32 in the directional differentiation of induced pluripotent stem cells into hepatocytes

Y Xu, Y Wang, R Qi, K Li, X Wang, X Li… - International Journal of …, 2024 - ncbi.nlm.nih.gov
… and enhanced the expression of the aforementioned hepatic … and AFP, exhibited marked
increases in the upregulated … , hepatitis, cirrhosis and hepatocellular carcinoma 43 . Most …

Connexin 32-mediated cell-cell communication is essential for hepatic differentiation from human embryonic stem cells

J Qin, M Chang, S Wang, Z Liu, W Zhu, Y Wang… - Scientific reports, 2016 - nature.com
… and hepatocyte functional maintenance, we hypothesized that enhanced hepatocyte maturity
novel function of connexin 32: marked enhancement of liver function in a hepatoma cell line

Downregulated connexin32 promotes EMT through the Wnt/β-catenin pathway by targeting Snail expression in hepatocellular carcinoma

Y Yang, N Zhang, J Zhu, XT Hong… - International …, 2017 - spandidos-publications.com
… Snail expression, and the enhanced Snail was due to … size, TNM stage, background of liver
disease, or vascular embolus (all P>… (marked by red arrow) and cytoplasmic (marked by white …

Connexin32 deficiency exacerbates carbon tetrachloride-induced hepatocellular injury and liver fibrosis in mice

B Cogliati, S Crespo Yanguas, TC Da Silva… - Toxicology …, 2016 - Taylor & Francis
… Results: More pronounced liver damage and enhanced … may further burgeon into
hepatocellular carcinoma. In 2010, … Our results indicate that lack of Cx32 induces a marked

Gap junctions in liver disease: Implications for pathogenesis and therapy

M Hernández-Guerra, A Hadjihambi, R Jalan - Journal of hepatology, 2019 - Elsevier
… approaches the function of different connexins has been … This is of particular interest in
hepatocellular carcinoma (HCC) … enhancement of GJs, 42 provided the rationale to explore the …

[HTML][HTML] Connexin-based signaling and drug-induced hepatotoxicity

M Maes, M Vinken - Journal of clinical and translational research, 2017 - ncbi.nlm.nih.gov
… processes, such as in liver disease and hepatotoxicity [28,29]… in rat liver epithelial cells and
human hepatoma cells triggers … In addition, clofibrate enhanced the appearance of Cx43 in …

[PDF][PDF] Role of connexins, pannexins and their channels in liver cancer

K Leroy - 2023 - researchportal.vub.be
… (HCC), which often develops from chronic liver disease. Risk factors for the development of
… the Cx expression and functionality of gap junctions in liver cancer cell lines. Cell lines are …

A role of connexin 43 on the drug-induced liver, kidney, and gastrointestinal tract toxicity with associated signaling pathways

R Katturajan, SE Prince - Life sciences, 2021 - Elsevier
… consumption in cells, collectively say organ damage [20,21]. … the liver, numerous toxicants
are reported to have liver damagecell line, results in round-shaped loosely attached cells and …