A robust data-driven genomic signature for idiopathic pulmonary fibrosis with applications for translational model selection

R Ammar, P Sivakumar, G Jarai, JR Thompson - PLoS One, 2019 - journals.plos.org
… to the disease signature. Our work defines a robust genetic signature for IPF providing a …
as enables the identification of preclinical models that most closely resemble human IPF. …

Molecular signatures of idiopathic pulmonary fibrosis

IR Konigsberg, R Borie, AD Walts… - American journal of …, 2021 - atsjournals.org
… Volcano plots depicting features that are statistically significant in idiopathic pulmonary
fibrosis (IPF) lung tissue compared with control lung tissue at a false discovery rate <0.05 (blue …

[HTML][HTML] A novel prognostic signature for idiopathic pulmonary fibrosis based on five-immune-related genes

L Qiu, G Gong, W Wu, N Li, Z Li, S Chen… - … of Translational …, 2021 - ncbi.nlm.nih.gov
… Therefore, we constructed a molecular genomic signature to predict the prognosis of IPF …
the performance of the genomic signature in the validation cohort. The signature showed an …

MicroRNA and protein-coding gene expression analysis in idiopathic pulmonary fibrosis yields novel biomarker signatures associated to survival

NG Casanova, T Zhou, ML Gonzalez-Garay… - Translational …, 2021 - Elsevier
… (miRNA) gene signatures as biomarkers in patients with Idiopathic pulmonary fibrosis (IPF), …
identify potential miRNA or gene signatures to serve as novel biomarkers for survival in IPF …

Detecting the molecular system signatures of idiopathic pulmonary fibrosis through integrated genomic analysis

I Gangwar, N Kumar Sharma, G Panzade, S Awasthi… - Scientific reports, 2017 - nature.com
Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing IIP that has no effective therapy with
a mortality rate higher than many cancers; median survival from the time of diagnosis being …

The peripheral blood proteome signature of idiopathic pulmonary fibrosis is distinct from normal and is associated with novel immunological processes

DN O'Dwyer, KC Norman, M Xia, Y Huang… - Scientific reports, 2017 - nature.com
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal … Thus, in this paper we apply
a novel large scale high … to identify a unique IPF proteome signature and give insight into …

Genome-wide association study across five cohorts identifies five novel loci associated with idiopathic pulmonary fibrosis

RJ Allen, A Stockwell, JM Oldham, B Guillen-Guio… - Thorax, 2022 - thorax.bmj.com
Idiopathic pulmonary fibrosis (IPF) is a chronic lung condition with poor survival times. We
previously published a genome-… size estimates, we performed a genome-wide meta-analysis …

Pan-transcriptome-based candidate therapeutic discovery for idiopathic pulmonary fibrosis

Y Wang, JK Yella, S Ghandikota… - Therapeutic …, 2020 - journals.sagepub.com
… nintedanib, for treatment of patients with idiopathic pulmonary fibrosis (IPF). However, neither
… minimal effect on IPF-specific gene signature or alter translational modifications involved in …

Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis

B Ng, J Dong, G D'Agostino, S Viswanathan… - Science translational …, 2019 - science.org
Idiopathic pulmonary fibrosis (IPF) is a fibrotic lung disease characterized by epithelial
injury and chronic activation of invasive fibroblasts that deposit and remodel the extracellular …

Integrated plasma proteomics and lung transcriptomics reveal novel biomarkers in idiopathic pulmonary fibrosis

P Sivakumar, R Ammar, JR Thompson, Y Luo… - Respiratory …, 2021 - Springer
translational biomarker studies. Transcriptomic and proteomic disease signatures generated
from clinically relevant human … ” modeling can enable translational disease understanding, …