The nuclear cap-binding complex as choreographer of gene transcription and pre-mRNA processing

X Rambout, LE Maquat - Genes & development, 2020 - genesdev.cshlp.org
… The largely nuclear cap-binding complex (CBC) binds to the … transcription elongation,
cotranscriptional pre-mRNA splicing, … of pre-mRNA splicing, being largely cotranscriptional, is also …

The cap-binding complex CBC and the eukaryotic translation factor eIF4E: co-conspirators in cap-dependent RNA maturation and translation

JC Mars, M Ghram, B Culjkovic-Kraljacic, KLB Borden - Cancers, 2021 - mdpi.com
… Factors that bind this moiety can control the fate of the RNA. … producing multiple mRNAs from
the same pre-mRNA [1]. About … from CBC interact with RNAs co-transcriptionally and act in …

The diverse requirements of ARS2 in nuclear cap-binding complex-dependent RNA processing

C O'Sullivan, PL Howard - Rna & Disease, 2017 - smartscitech.com
… cap is co-transcriptionally bound by the nuclear cap-binding … cleavage by the histone
pre-mRNA cleavage complex (HCC), … in low salt conditions; however, the DUF mutant could bind

Mechanism and regulation of Co-transcriptional mRNP assembly and nuclear mRNA export

W Wende, P Friedhoff, K Sträßer - The biology of mRNA: structure and …, 2019 - Springer
… mRNP begins co-transcriptionally when nuclear mRBPs bind to … The cap-binding complex
(CBC) binds to the m 7 G-cap … of the nascent pre-mRNA by the THO complex and other …

Into the basket and beyond: the journey of mRNA through the nuclear pore complex

A Ashkenazy-Titelman, Y Shav-Tal… - Biochemical …, 2020 - portlandpress.com
… ′-ends of the pre-mRNA via the cap-binding complex (CBC) [… from pre-mRNA splicing can
cause a defect in mRNA export. … that NXF1 can also bind co-transcriptionally and after splicing…

Nuclear mRNA maturation and mRNA export control: from trypanosomes to opisthokonts

S Kramer - Parasitology, 2021 - cambridge.org
… maturation steps occur co-transcriptionally. During maturation, the pre-mRNA interacts
with … The nuclear cap binding complex of trypanosomes has only one conserved subunit (CBP20) …

The nuclear pore complex: a comprehensive review of structure and function

SP Stawicki, JM Steffen - International Journal of Academic …, 2017 - journals.lww.com
… following TBP transport was accompanied by permanent channel … The CBC binds to the
nascent pre-mRNA shortly after … ribosomal ribonucleic acids utilizing cap-binding complex. The …

Distinct functions of the cap-binding complex in stimulation of nuclear mRNA export

R Sen, P Barman, A Kaja, J Ferdoush… - … and Cellular Biology, 2019 - Taylor & Francis
Cap-binding complex (CBC) associates cotranscriptionally … (CBC), a heterodimer of Cbp20
and Cbp80, binds to the cap … splicing of the first intron of pre-mRNA of Sus1, a component of …

Promoter proximal U1snRNP-dependent pre-mRNA processing defects in human coagulation factor 7 deficiency

I PETROVIC - 2018 - sfera.unife.it
… The 5’end capping with a methylated guanosine analogue occurs co-transcriptionally.
When … At the first splicing step U1snRNA binds to the 5’ splice site of pre-mRNA, by basepairing …

The great escape: mRNA export through the nuclear pore complex

P De Magistris - International journal of molecular sciences, 2021 - mdpi.com
… will be co-transcriptionally deposited onto the pre-mRNA at … both the cap binding complex
(CBC) and of the exon junction … export involved the giant Balbiani Ring transcripts in the insect …