Nucleocytoplasmic transport of RNAs and RNA–protein complexes

KE Sloan, PE Gleizes, MT Bohnsack - Journal of molecular biology, 2016 - Elsevier
pre-mRNA is capped and the cap binding complex (CBC) and transcription and export
complex (TREX) are co-transcriptionally … , it has been shown that the Balbiani ring pre-mRNP is …

The mRNA cap-binding protein Cbc1 is required for high and timely expression of genes by promoting the accumulation of gene-specific activators at promoters

T Li, N De Clercq, DA Medina, E Garre… - … et Biophysica Acta (BBA …, 2016 - Elsevier
… cerevisiae cap-binding protein Cbc1/Sto1 binds mRNA co-transcriptionally and acts as a
key … As nascent pre-mRNA emerges from the RNA exit channel of RNA polymerase II (RNAPII) …

Imaging organization of RNA processing within the nucleus

J Biswas, W Li, RH Singer… - Cold Spring Harbor …, 2021 - cshperspectives.cshlp.org
… on an individual pre-mRNA before the pre-mRNA is committed … RNA-binding proteins (RBPs)
bind cotranscriptionally to … We would expect a dwell time to accompany the association of …

eIF4E orchestrates mRNA processing, RNA export and translation to modify specific protein production

JC Mars, B Culjkovic-Kraljacic, KLB Borden - Nucleus, 2024 - Taylor & Francis
… NCBP2 recognizes the cap co-transcriptionally while the accessory … the nuclear importer
Importin 8 also binds to the cap-binding … For some mRNAs, eIF4E binds both the pre-mRNA and …

Nascent RNA and the coordination of splicing with transcription

KM Neugebauer - Cold Spring Harbor Perspectives in …, 2019 - cshperspectives.cshlp.org
… of precursor messenger RNA (pre-mRNA) to messenger RNA (… how spliceosomes assemble
co-transcriptionally on individual … The nuclear cap-binding complex interacts with the U4/U6.…

The nuclear cap-binding complex mediates meiotic silencing by unpaired DNA

LM Decker, H Xiao, EC Boone… - G3: Genes …, 2017 - academic.oup.com
… that bind to the 5′ cap, also known as cap-binding proteins (… the heterodimeric cap-binding
complex (CBC), which binds to the … role for Cbc2 in meiosis via splicing of MER3 pre-mRNA. …

HIV-1 gag blocks selenite-induced stress granule assembly by altering the mRNA cap-binding complex

A Cinti, V Le Sage, M Ghanem, AJ Mouland - MBio, 2016 - Am Soc Microbiol
… Blocking Se-induced SG assembly via interference with a component of the cap-binding
complex is a distinct mechanism and reinforces the notion that SGs are deleterious to HIV-1 …

RNA transport from transcription to localized translation: a single molecule perspective

E Basyuk, F Rage, E Bertrand - RNA biology, 2021 - Taylor & Francis
… , cap-binding complexes, the exon-exon junction complex and poly-… that binds the pre-mRNA
co-transcriptionally, accompanies it … it was co-transcriptionally incorporated in Balbiani Ring

RNA export through the nuclear pore complex is directional

A Ashkenazy-Titelman, MK Atrash, A Boocholez… - Nature …, 2022 - nature.com
… ribosome recruitment and cap-binding proteins were detected … interact with the nascent
mRNA co-transcriptionally 31,46 , … recruitment of these proteins to the pre-mRNA, ending up in a …

New Insights into the Biochemistry and Cell Biology of RNA Recapping

JB Trotman - 2018 - rave.ohiolink.edu
… , the cap is bound by the nuclear cap-binding complex … Such diversity of cap-binding
proteins illustrates the importance of the … The majority of translation is directed by the cap-binding