Towards understanding pre-mRNA splicing mechanisms and the role of SR proteins

M Sahebi, MM Hanafi, AJ van Wijnen, P Azizi, R Abiri… - Gene, 2016 - Elsevier
… A by stabilizing the binding of two splicing factors, U1 and U2 (SF1). Similarly, the … factors
such as SR-proteins, which bind to exonic splicing enhancers (ESE) and stabilize the binding

Biological function and molecular mechanism of SRSF3 in cancer and beyond

J Xiong, Y Chen, W Wang, J Sun - Oncology Letters, 2022 - spandidos-publications.com
… During splicing, the serine/arginine-rich domain (RS) of the … binding protein (PTBP) 1 and
PTBP2 bind to exonic splicingbinding protein microtubule associated protein RP/EB family

Pre-mRNA splicing and its cotranscriptional connections

H Shenasa, DL Bentley - Trends in Genetics, 2023 - cell.com
… cotranscriptional binding to exonic and intronic splicing … and indirect contacts mediated by
a network of SR proteins [ … Putative protein:protein contacts between Pol II and splicing factors

Nascent RNA and the coordination of splicing with transcription

KM Neugebauer - Cold Spring Harbor Perspectives in …, 2019 - cshperspectives.cshlp.org
… with findings in the Balbiani ring of Chironomus tentans, where … of the SR protein family of
splicing factors revealed recruitment … or exonic sequences to track pre-mRNA transcription and …

USP15 and USP4 facilitate lung cancer cell proliferation by regulating the alternative splicing of SRSF1

T Das, EY Lee, HJ You, EEK Kim, EJ Song - Cell Death Discovery, 2022 - nature.com
splicing factor 1 (SRSF1), also known as pre-mRNA-splicing factor ASF1/SF2 is the archetype
member of the SR family … tumor-suppressor activity due to reduced binding with MYC [44]. …

Imaging organization of RNA processing within the nucleus

J Biswas, W Li, RH Singer… - Cold Spring Harbor …, 2021 - cshperspectives.cshlp.org
… increased loading of splicing factors but not RNA Pol II and reversed by splicing inhibition. …
RNA-binding proteins also can dictate alternative splicing changes, not only by competing …

A quantitative RT-PCR assay to monitor luciferase reporter mRNA levels

R Thomas - 2022 - escholarship.org
SR proteins belong to the serine/arginine family and recognize both exonic splice enhancers
(ESEs) and intronic splice … This relaxes the ring structure of the Balbiani transcript allowing …

[图书][B] Regulation and Modulation of Alternative Splicing Outcomes by RNA Binding Proteins

JA Ellis - 2023 - search.proquest.com
… To all my family, friends, and lab members for being an essential part of … proteins bind to
the expanded CCUG RNA repeats found in DM2, suggesting that these two splicing factors

Global co-transcriptional splicing in Arabidopsis and the correlation with splicing regulation in mature RNAs

S Li, Y Wang, Y Zhao, X Zhao, X Chen, Z Gong - Molecular plant, 2020 - cell.com
… exons and short introns, splice site recognition occurring predominantly by intron definition,
and the presence of a large number of SR proteins (a family of conserved splicing factors) ( …

[图书][B] The Impact of Mutations and Downmodulation of LUC7L2 and Other Splicing Factors on Alternative Splicing Landscapes in Leukemic Cells and Malignant …

CE Hershberger - 2020 - search.proquest.com
family of proteins are the orthologs of yeast splicing factor Luc7p, little is known about their
function in splicing. … SR proteins frequently recognize and bind to exonic sequences, and most …