… bevacizumab vs erlotinib alone on progression-free survival in patients with advanced EGFR-mutant non–small cell lung cancer: a phase 2 randomized clinical trial

TE Stinchcombe, PA Jänne, X Wang, EM Bertino… - JAMA …, 2019 - jamanetwork.com
… of erlotinib. The Cancer and Leukemia Group B trial 30406 was a randomized phase 2 clinical
trial that investigated erlotinib … agent rather than chemotherapy for the next clinical trial. A …

… plus cisplatin as adjuvant therapy in Chinese patients with stage IIIA EGFR mutation-positive non-small-cell lung cancer (EVAN): a randomised, open-label, phase 2 …

D Yue, S Xu, Q Wang, X Li, Y Shen, H Zhao… - The Lancet …, 2018 - thelancet.com
… To our knowledge, this is the first phase 2 clinical trial to … with stage IIIA NSCLC in the hope
of introducing an alternative to … with chemotherapy in Chinese patients with stage IIIA EGFR …

… therapy in unresectable stage III epidermal growth factor receptor mutation-positive non-small cell lung cancer: a multicenter, randomized, open-label, phase 2 trial

L Xing, G Wu, L Wang, J Li, J Wang, Z Yuan… - International Journal of …, 2021 - Elsevier
… versus chemotherapy (etoposide/cisplatin), both with … In a phase 2 study by Lee et al, 12
which compared E + RT versus … Our study suggests that E + RT might be a beneficial alternative

… versus erlotinib alone in patients with EGFR-positive advanced non-squamous non-small-cell lung cancer (NEJ026): interim analysis of an open-label, randomised …

H Saito, T Fukuhara, N Furuya, K Watanabe… - The Lancet …, 2019 - thelancet.com
… status of 2 or lower, no previous chemotherapy for advanced … identified two phase 2 trials
that assessed the activity of erlotinib … The BELIEF study showed that combined therapy with …

Randomized phase 2 study of tivantinib plus erlotinib versus single-agent chemotherapy in previously treated KRAS mutant advanced non-small cell lung cancer

DE Gerber, MA Socinski, JW Neal, HA Wakelee… - Lung Cancer, 2018 - Elsevier
… a subset analysis of an earlier trial of erlotinib plus tivantinib (a small molecule MET inhibitor),
we conducted this randomized phase 2 trial of erlotinib plus tivantinib in previously treated …

Randomized phase II study of fulvestrant and erlotinib compared with erlotinib alone in patients with advanced or metastatic non-small cell lung cancer

EB Garon, JM Siegfried, LP Stabile, PA Young… - Lung Cancer, 2018 - Elsevier
Alternative approaches would also include aromatase inhibitors such as exemestane
alone (NCT02666105) or in combination with chemotherapy (carboplatin and pemetrexed) (…

A phase II trial of erlotinib monotherapy in advanced pancreatic cancer as a first-or second-line agent

C Fountzilas, R Chhatrala, N Khushalani, W Tan… - Cancer chemotherapy …, 2017 - Springer
… .3 study, two large phase III studies provided alternative first-… single-arm phase II study of
erlotinib monotherapy in patients … deemed ineligible for cytotoxic chemotherapy. At the time this …

… -line treatment of patients with EGFR wild-type advanced non-small-cell lung cancer (ECOG-ACRIN 1512): a randomised, controlled, open-label, multicentre, phase 2 …

JW Neal, SE Dahlberg, HA Wakelee, SC Aisner… - The lancet …, 2016 - thelancet.com
… Clinical data in support of this trial included a phase 2 study of … refractory to chemotherapy
often still received erlotinib in the … for each comparison was 58 events under the alternative

A randomized Phase 2 study to compare erlotinib with or without bevacizumab in previously untreated patients with advanced non–small cell lung cancer with EGFR …

Y Lee, HR Kim, MH Hong, KH Lee, KU Park, GK Lee… - Cancer, 2023 - Wiley Online Library
… this randomized Phase 2 study to evaluate the efficacy and toxicity of the combination erlotinib
and … Although this study failed to meet the primary end point, it demonstrated that patients …

Results from the phase III randomized trial of onartuzumab plus erlotinib versus erlotinib in previously treated stage IIIB or IV non–small-cell lung cancer: METLung

DR Spigel, MJ Edelman, K O'Byrne… - Journal of Clinical …, 2017 - ascopubs.org
… Results from a phase II study of onartuzumab plus erlotinib in … were improved compared
with placebo plus erlotinib 17 and … , with studies comparing EGFR TKIs and chemotherapy in a …