… The most frequent side effect is myelosuppression, which makes it difficult to combine with
… A pretreatment tumour biopsy from a liver metastasis was either obtained as archival tissue …

… The presence of AzaD, whether randomly incorporated into DNA … Results from the latter two
studies indicate that the activation of … Generally, a combination of both drugs is synergistically …

… Synergistic antineoplastic action of 5-aza-2’deoxycytidine (decitabine) in combination with
different inhibitors of enhancer of zeste homolog 2 (EZH2) on human lung carcinoma cells. J …

… We next evaluated whether the combined treatments had an effect on metabolic activity
of uninfected CD8 + ‐depleted PBMCs. To this end, we prepared ex vivo cultures of CD8 + ‐…

… ) and decitabine (5-aza-2′-deoxycytidine) are DNA … was observed between either
combination arm versus azacitidine … same combination treatment in phase III versus prior phase II…

… Phase II studies have also suggested a beneficial effect of IL-… reduce side effects of multiple
combined treatments and … We have not presently investigated whether, as in type 1 diabetes …

… , guided by pharmacokinetic and pharmacodynamic observations, evaluated whether …
DNA methylation changes after 5-aza-2-deoxycytidine therapy in patients with leukemia. …

… ), we set out to determine whether targeting DNA methylation … with previous single-arm
phase II studies using an epigenetic … agent 5-aza-2′-deoxycytidine (decitabine) in combination …

… , we performed a multicenter phase II clinical trial combining 5-… whether this combination
is more efficacious than either … the optimal dose and schedule may be of the combination. A …

… effects were observed when combined with other chemo- and immune-therapies [8]. However,
it is not known whether … has no effect on 5-azacitidine treatment in either SKM-1 or HL-60 …