… The explanation that lower po acute toxicity of 7-MEOTA depends only on differences in …
peak area ratio tacrine or 7-MEOTA/IS versus the tacrine or 7-MEOTA concentration showed a …

… 7-methoxytacrine (7-MEOTA), since this analogue of tacrine is … differences between tacrine
and the 7-MEOTA/K576/K577 group (p = 0.5895); (ii) significant differences between tacrine …

… to be a culprit of toxicity) was found compared to tacrine and 7-MEOTA, probably due to the
… and characterization of ten tacrine and ten 7-MEOTA dihydroxymetabolites (accounting for a …

… 7-MEOTA was evaluated as a comparative molecule in all measurements; MAO-A
inhibition by the compounds was compared … Our finding that all compounds of the tacrine/7-MEOTA/6-…

… toxicity, we first incubated HLMs together with tacrine derivatives (tacrine, 7-MEOTA, 7-Ph-O-…
Specifically, we compared the metabolic profiles of tacrine and its derivatives using the well-…

… in HepG2 cell line in comparison with tacrine at 24h and 0-50 μM and it could be observed
that compound 68 is characterized by a safer profile compared to compound 65 and tacrine. …

… Our findings provide evidence solely for a comparison of … tacrine effects stem from long-term
and repeated administration [86]. Since we do not have all these data in hand for 7-MEOTA-…

… tacrine led to its withdrawal from clinical use several years later [5]. Many studies show that
chemical modification of tacrine reduces its toxicity, eg: 7-methoxytacrine (7-MEOTA… compare …

… 7-MEOTA was found to be markedly less toxic than tacrine also for dogs and rabbits. …
lower compared with parent compound tacrine and eight times lower compared with 7-MEOTA. …

… 7-MEOTA, was developed as a derivative of tacrine (1,2,3,4-tetrahydroacridin-9-amine, THA),
and was the first AD drug approved by FDA for clinical practice [8]. 7-MEOTA … by comparing …