Cell-specific and athero-protective roles for RIPK3 in a murine model of atherosclerosis
S Colijn, V Muthukumar, J Xie… - Disease models & …, 2020 - journals.biologists.com
… In addition, we saw no significant differences in lesion size, necrotic core size, macrophage
area, smooth muscle cell area, collagen area or calcification in the athero-prone aortic roots …
area, smooth muscle cell area, collagen area or calcification in the athero-prone aortic roots …
Targeting macrophage necroptosis for therapeutic and diagnostic interventions in atherosclerosis
D Karunakaran, M Geoffrion, L Wei, W Gan… - Science …, 2016 - science.org
… of macrophage cell death that drive necrotic core formation in atherosclerosis and suggest
… into how atherogenic ligands drive necrotic core development to better devise therapies that …
… into how atherogenic ligands drive necrotic core development to better devise therapies that …
[HTML][HTML] Macrophage death as a pharmacological target in atherosclerosis
W Martinet, I Coornaert, P Puylaert… - Frontiers in …, 2019 - frontiersin.org
… laboratory developed different pharmacological strategies to selectively deplete macrophages
in atherosclerotic plaques … Macrophage necrosis is a key feature in the pathogenesis of …
in atherosclerotic plaques … Macrophage necrosis is a key feature in the pathogenesis of …
[HTML][HTML] The role of RIPK1 and RIPK3 in cardiovascular disease
E DeRoo, T Zhou, B Liu - International Journal of Molecular Sciences, 2020 - mdpi.com
… atherosclerosis involves the development of fatty streaks upon the vascular wall that evolve
into lipid and macrophage rich necrotic … Low-density-lipoprotein (LDL)-rich macrophage and …
into lipid and macrophage rich necrotic … Low-density-lipoprotein (LDL)-rich macrophage and …
RIPK1 Expression Associates With Inflammation in Early Atherosclerosis in Humans and Can Be Therapeutically Silenced to Reduce NF-κB Activation and …
D Karunakaran, MA Nguyen, M Geoffrion, D Vreeken… - Circulation, 2021 - Am Heart Assoc
… a cell that shares morphological features with necrosis. The balance of RIPK1 signaling in
… macrophage necroptosis and the development of the necrotic core within the atherosclerotic …
… macrophage necroptosis and the development of the necrotic core within the atherosclerotic …
miR-223-3p Prevents Necroptotic Macrophage Death by Targeting Ripk3 in a Negative Feedback Loop and Consequently Ameliorates Advanced Atherosclerosis
Y Jia, L Cheng, J Yang, J Mao, Y Xie… - … and Vascular Biology, 2024 - Am Heart Assoc
… contribution of each death mode to the necrotic core formation during atherosclerosis
development. Although we found that lesional macrophages can die either through apoptosis or …
development. Although we found that lesional macrophages can die either through apoptosis or …
Regulated necrosis in atherosclerosis
P Puylaert, M Zurek, KJ Rayner… - … , and vascular biology, 2022 - Am Heart Assoc
… Apart from the formation and enlargement of a central necrotic core, necrotic macrophages
… of plaque development, 39 suggesting that macrophage necroptosis plays a major role in …
… of plaque development, 39 suggesting that macrophage necroptosis plays a major role in …
[HTML][HTML] The function, regulation and mechanism of programmed cell death of macrophages in atherosclerosis
C Liu, Z Jiang, Z Pan, L Yang - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
… , other studies confirm that macrophage apoptosis positively regulates the development of
… reduced, and the number of programmed necrotic macrophages in the lesion was less than …
… reduced, and the number of programmed necrotic macrophages in the lesion was less than …
[HTML][HTML] RIP1/RIP3/MLKL mediates myocardial function through necroptosis in experimental autoimmune myocarditis
Y Wu, Z Zheng, X Cao, Q Yang, V Norton… - Frontiers in …, 2021 - frontiersin.org
… , acute heart failure, and atherosclerosis, no compelling evidence is … /RIP3-mediated
necroptosis plays a critical role in developing … by mononuclear macrophage infiltration, necrosis of …
necroptosis plays a critical role in developing … by mononuclear macrophage infiltration, necrosis of …
[HTML][HTML] RIP1/RIP3-regulated necroptosis as a target for multifaceted disease therapy
Y Liu, T Liu, T Lei, D Zhang, S Du… - International …, 2019 - spandidos-publications.com
… RIP1/RIP3‑mediated necroptosis, explored the functions of RIP1/… , it is acknowledged that
necrosis can also be regulated in a … that RIP3-mediated necroptosis in atherosclerotic plaques …
necrosis can also be regulated in a … that RIP3-mediated necroptosis in atherosclerotic plaques …