… A small molecule antagonist of chemokine receptors CCR1 and CCR3. Potent inhibition
of eosinophil function and CCR3-mediated HIV-1 entry. …

… TAK-779 is the only CCR5 antagonist with strong interaction … 3) is a dual chemokine receptor
(CCR2/CCR5) antagonist … can also act on CCR3 to activate eosinophils, but the activity is …

… potent and selective antagonist of the CCR3 signaling cascade. Inhibition through a biased
mode of antagonism … as a high-affinity unbiased antagonist of CCR3 and CCR1, was found …

… from their respective receptors CXCR4, CCR3, and CCR5 (… design of small molecules to
modulate chemokine receptors. … pockets in other chemokine receptors, including CCR1, CCR5, …

… of the CCR3 antagonist GW766994 in eosinophilic asthma did … DPC-168 is a potent CCR3
antagonist that causes CYP and … A small molecule antagonist of chemokine receptors CCR1 …

… we discuss CC chemokine receptors CCR1, CCR2, CCR3, and CCR4 … H4 receptor and
therefore may act on eosinophils [55]. … CCL2 is also an antagonist of CCR3 [87]. CCL7 can also …

… CCR3 small-molecule antagonists inhibited intracellular calcium mobilization and eosinophil
chemotaxis induced by CCR3 … Small molecules do not bear the risk of immunogenicity like …

… of CCR3 is associated with chemotaxis of eosinophils, thus … therapeutic small molecules
targeting any of these receptors … –G i interface among the complexes of CCL15–CCR1–G i (…

… process orchestrated by small molecules of 15 kDa called chemokines. … CCR3 is one of the
most relevant chemokine receptors in asthma because it triggers the migration of eosinophils …

… CC chemokine receptor 3 CD … For unclear reasons, small molecule CCR3 antagonists
have … In summary, the CCR3 R3-2-1 peptide is a novel biased antagonist that inhibits …