… In particular, PALB2 is emerging as the most important BC predisposition gene after BRCA1
and BRCA2 [122,123], but at the same time, it is still classified as a moderate penetrance …

… Enrichment of pathogenic variants were identified in 4 non-BRCA genes associated with
breast cancer risk: ATM (odds ratio [OR], 2.97; 95% CI, 1.67-5.68), CHEK2 (OR, 2.19; 95% CI, …

… Hereditary Breast and Ovarian Cancer (HBOC) Syndrome … genes: breast cancer susceptibility
gene 1 (BRCA1), which was first described in 1994, and breast cancer susceptibility gene …

… and putative breast cancer susceptibility genes, plus BRCA1 and BRCA2, in 684 women
affected by breast/ovarian cancer and with a strong family history of breast cancer. Protein-…

… of breast and ovarian cancer risk associated with many clinically tested genes, and independent
of family cancer … After 20 years of testing for BRCA1/2 only, clinicians now increasingly …

… We also describe their association with ovarian cancer for the first time. … cancer risk as well
as the relation with other cancer types. … in BRCA1-BRCA2 genes. In the last decade several …

… - and/or low-penetrance genes. In Central and South … prevalence of BRCA1/2 mutations and
other susceptibility genes that … pathogenic BRCA variants and other BC susceptibility genes. …

… breast cancer risk in BRCA 1 and BRCA2 heterozygotes have been published. Rebbeck et
al [2005] evaluated breast cancer risk … risk variant: breast and ovarian cancer risk estimation …

… BRCA1 and BRCA2 were the only genes with a Definitive assertion for predisposition to
both breast and ovarian cancers… for breast or ovarian cancer risk and the EPCAM gene. This …

… variants in the tumor suppressor genes BRCA1 and BRCA2 are widely associated with
an elevated risk of ovarian cancer (OC). As only ~15% of OC individuals carry the BRCA1/2 …