[HTML][HTML] Differences in Ovarian and Other Cancers Risks by Population and BRCA Mutation Location

M Sekine, K Nishino, T Enomoto - Genes, 2021 - mdpi.com
… association of ovarian cancer risk and BRCA mutation … BRCA1/2 genes for epithelial ovarian
cancer, we picked up large-scale epidemiological studies of more than 500 ovarian cancer

Identifying causality, genetic correlation, priority and pathways of large-scale complex exposures of breast and ovarian cancers

S Si, J Li, MA Tewara, H Li, X Liu, Y Li, X Chen… - … Journal of Cancer, 2021 - nature.com
… , genetic statistical methods were used to identify the relations between large-scale
cancer-related exposures and breast and ovarian cancers. Thirty-one exposures were robust risk

[HTML][HTML] Evaluation of copy-number variants as modifiers of breast and ovarian cancer risk for BRCA1 pathogenic variant carriers

LC Walker, L Marquart, JF Pearson… - European Journal of …, 2017 - nature.com
… in BRCA1 or BRCA2 have reported strong associations between single-nucleotide
polymorphisms (SNPs) and cancer risk… ) with breast or ovarian cancer risk in a cohort of 2500 …

[HTML][HTML] Identification of a novel gene signature predicting response to first-line chemotherapy in BRCA wild-type high-grade serous ovarian cancer patients

M Buttarelli, A Ciucci, F Palluzzi, G Raspaglio… - … & Clinical Cancer …, 2022 - Springer
… Likewise, UQCC1, a protein involved in cytochrome b translation and/or stability, has been
recently identified as a candidate ovarian cancer susceptibility gene [64]. Interestingly, it has …

[HTML][HTML] Rare germline genetic variants and the risks of epithelial ovarian cancer

M Pavanello, IHY Chan, A Ariff, PDP Pharoah… - Cancers, 2020 - mdpi.com
BRCA1 and BRCA2 These two major breast/ovarian cancer susceptibility genes encode …
Due to the magnitude of ovarian cancer risk associated with variants in BRCA1 and BRCA2, …

[HTML][HTML] An immune-centric exploration of BRCA1 and BRCA2 germline mutation related breast and ovarian cancers

E Przybytkowski, T Davis, A Hosny, J Eismann… - BMC cancer, 2020 - Springer
… We found that BRCA1/2 germline related breast and ovarian cancers do not represent a …
similar to sporadic cancers. All breast and ovarian BRCA1/2 related tumors are characterized by …

Germline mutations in cancer susceptibility genes in a large series of unselected breast cancer patients

J Sun, H Meng, LU Yao, M Lv, J Bai, J Zhang… - Clinical Cancer …, 2017 - AACR
… mutations in the 46 cancer susceptibility genes (including BRCA1 and BRCA2) using a
62-… mutations in other breast and/or ovarian cancer susceptibility genes (BOCG) beyond …

Assessment of Multifactor Gene–Environment Interactions and Ovarian Cancer Risk: Candidate Genes, Obesity, and Hormone-Related Risk Factors

JL Usset, R Raghavan, JP Tyrer, V McGuire… - Cancer Epidemiology …, 2016 - AACR
… a set of candidate genes related to steroid biosynthesis, estrogen signaling, and IGFs, as
we hypothesize that genetic variants within these candidate genes modify EOC risk and that …

Screening of HELQ in breast and ovarian cancer families

LM Pelttari, L Kinnunen, JI Kiiski, S Khan, C Blomqvist… - Familial cancer, 2016 - Springer
breast and ovarian cancer susceptibility gene in the Finnish population. However, we cannot
rule out rare risk-… The most important known susceptibility genes are BRCA1 and BRCA2 …

[HTML][HTML] Gene Panel Tumor Testing in Ovarian Cancer Patients Significantly Increases the Yield of Clinically Actionable Germline Variants beyond BRCA1/BRCA2

A Barbosa, P Pinto, A Peixoto, J Guerra, C Pinto… - Cancers, 2020 - mdpi.com
… However, germline variants in other genes besides BRCA1 and BRCA2 are associated
with ovarian cancer predisposition, which would be missed by a genetic testing aimed only at …