Stabilities and instabilities in transgene expression
P Meyer - Transgenic plant research, 2022 - taylorfrancis.com
… to the presence of multiple copies of the transgene or homologous … its transcription, or by
post transcriptional processes that … High frequency, heat treatment-induced inactivation of the …
post transcriptional processes that … High frequency, heat treatment-induced inactivation of the …
GC-rich coding sequences reduce transposon-like, small RNA-mediated transgene silencing
LV Sidorenko, T Lee, A Woosley, WA Moskal… - Nature plants, 2017 - nature.com
… or translational repression, resulting in post-transcriptional gene … In addition to the increased
frequency of methylated … biased LC-PUFA transgenes with repeated regulatory sequences …
frequency of methylated … biased LC-PUFA transgenes with repeated regulatory sequences …
[PDF][PDF] An RB-EZH2 complex mediates silencing of repetitive DNA sequences
… Repetitive genomic regions include tandem sequence repeats and interspersed repeats,
such as … We anticipate that EZH2 inhibitors will cause widespread de-repression of repetitive …
such as … We anticipate that EZH2 inhibitors will cause widespread de-repression of repetitive …
Controlled DNA double-strand break induction in mice reveals post-damage transcriptome stability
… evidence for persistent transcriptional repression in response to … Here, we generated a
transgenic mouse model, which … structures as well as canonical tandem repeats (57,58). …
transgenic mouse model, which … structures as well as canonical tandem repeats (57,58). …
Good News for Nuclear Transgene Expression in Chlamydomonas
M Schroda - Cells, 2019 - mdpi.com
… Suppression of SET3 by RNAi released the transcriptional silencing of tandemly repeated
transgenes … indeed reported an increased frequency of high-level transgene expression in a …
transgenes … indeed reported an increased frequency of high-level transgene expression in a …
[HTML][HTML] The road less traveled: strategies to enhance the frequency of homology-directed repair (HDR) for increased efficiency of CRISPR/Cas-mediated transgenesis
S Devkota - BMB reports, 2018 - ncbi.nlm.nih.gov
… in the reversal of HDR repression and increased HDR in G1 cells (52). … DNA, but in reverse
orientation. This strategy excludes the possibility of repeated cleavage of donor DNA after …
orientation. This strategy excludes the possibility of repeated cleavage of donor DNA after …
Transgenic clustered regularly interspaced short palindromic repeat/Cas9-mediated viral gene targeting for antiviral therapy of Bombyx mori nucleopolyhedrovirus
… ) genome DNA to promote virus clearance in silkworms. We demonstrate that transgenic …
deletions in BmNPV genomes, and thus exhibit robust suppression of BmNPV proliferation. …
deletions in BmNPV genomes, and thus exhibit robust suppression of BmNPV proliferation. …
Propagation of Polycomb-repressed chromatin requires sequence-specific recruitment to DNA
F Laprell, K Finkl, J Müller - Science, 2017 - science.org
… and heritably maintained over multiple cell generations. For … the >dpp WE –TZ transgene
in the absence of PRE DNA. … gene repression after PRE excision in animals in which DNA …
in the absence of PRE DNA. … gene repression after PRE excision in animals in which DNA …
[PDF][PDF] An abundant class of non-coding DNA can prevent stochastic gene silencing in the C. elegans germline
… only transgenes with the longest introns (700–900 bps) were expressed at high frequency …
-1 introns were repeated within transgenes; thus all three transgenes are relatively repetitive. (…
-1 introns were repeated within transgenes; thus all three transgenes are relatively repetitive. (…
[PDF][PDF] Regulation of rice tillering by RNA-directed DNA methylation at miniature inverted-repeat transposable elements
… In this study, we find that RdDM suppresses rice tillering. One … tillering not through
transcriptional repression or activation of … All of the transgenic plants generated in this study are in …
transcriptional repression or activation of … All of the transgenic plants generated in this study are in …