… 6 as well as in the mouse two-compartment model 13 . The results of VEGF distribution and
… We applied the three-compartment model of VEGF distribution to predict the concentration …

… Additionally, our model predicts that VEGF isoform-specific properties … in murine systems
expressing single VEGF isoforms. … models to further capture the complexity of VEGF distribution …

… a two-compartment model (E, X) developed by Wu et al. (2012). Bevacizumab is a VEGF
blocker that binds to the VEGF … , in the mice used to build our model (25 g nude mice with total …

… in mice (17). In addition, Chetty et al. also developed a PBPK … obtained by fitting a two-compartment
model with first-order … the distribution volume of endogenous and anti-VEGF IgG 1 …

… growth factors such as vascular endothelial growth factor (VEGF) to their … VEGF and its
cognate receptor … We ignored the effect of other VEGF receptors such as neuropilin-1 (NRP1) …

… Types of PK Models to Characterize the ADME Processes of TPs … PK model for TPs may be
a classic two-compartment model with linear and/or nonlinear clearance. This model appears …

… of native IgG using two-compartment model in human and … space and hence slower
distribution from vascular to … is higher than the reported value in the mouse PK study, ie 860 nM (…

… and mouse sFlt-1 and inhibited VEGF binding to sFlt-1 in a competitive manner. Proof-of-concept
studies in the mdx mouse model of … of 21B3 led to elevated VEGF levels, increased …

… improve NP delivery to solid tumors, the tumor models used … phased array mouse brain
surface coil for reception. The … Assuming a two-compartment model [22] and a population …

… escape in response to antiangiogenic/anti-VEGF therapies. … possibility to develop ⿿two-compartment⿿
targeting agents … In this context, several murine models have shown that ectopic …