… Crystal structure of the complex between human AChE and C-… Aβ oligomerizes into insoluble
fibrils, forming amyloid senile … Oligomerized Aβ has a broad spectrum of neurotoxic effects: …

… of amyloid beta-peptides into fibrils which is more toxic than Aβ fibrils (Chacón et al., 2003[11…
troxerutin attenuates Aβ 1-42-induced deleterious effects in the hippocampus of rats. This is …

… plaques and the accumulation of neurofibrillary tangles in the brain of patients with AD [21]. …
Aβ aggregation in vitro, resulting in Aβ-AChE complexes that are more toxic than Aβ fibrils [33…

… the complex is … Aβ aggregates across the Blood Brain Barrier (BBB) (Mohamed et al., 2015).
Donepezil exerts a neuroprotective effect by reducing the amount of the toxic form of Aβ-fibril …

… enhance Aβ aggregation, making it more toxic than Aβ fibrils [… Aβ and pTAU expression in
the hippocampus of pin+Aβ1-42 … Acetylcholinesterase-Aβ Complexes Are More Toxic than Aβ …

… effect on the neuronal communication network. NDs are a group of complex diseases that
arise in different brain … ), stabilizing Aβ conformations that do not facilitate oligomers or fibril …

… The βA–AChE complex is more neurotoxic than βA … In addition, this drug would act to promote
the formation of non-toxic Aβ … Salvianolic Acid B inhibited the formation of α-synuclein fibrils…

… The toxicity of these complexes is greater than the Aβ fibrils, … , reduced the MDA levels in
the brain of AD transgenic mice. … Aβ-mediated oxidative stress because of its protective effect …

… Aβ accumulates and aggregates within the brain causing the … The Aβ-AChE forms a stable
complex further leading to the … and Ser26 on Aβ fibrils, and this effect was enhanced with the …

… is more likely to form oligomers of Aβ) has complex toxic mechanisms … inhibit the formation
of Aβ fibrils and the toxicity of Aβ to nerve cells. … acetylcholinesterase–Aβ peptide [49,50]. …