[HTML][HTML] Role of CFTR in epithelial physiology

V Saint-Criq, MA Gray - Cellular and Molecular Life Sciences, 2017 - Springer
… as by fluid secretion arising from submucosal glands. Indeed, … was CFTR-dependent but
that although fluid secretion was … in acinar cells [114, 115], and is essential for electrolyte and …

Airway submucosal glands from cystic fibrosis swine suffer from abnormal ion transport across the serous acini, collecting duct, and ciliated duct

X Luan, JS Tam, S Jagadeeshan… - … of Physiology-Lung …, 2020 - journals.physiology.org
… of the fluid produced by the individual submucosal glandsCFTR-dependent gland secretion,
triggered serous acini epithelia … Acinar origin of CFTR-dependent airway submucosal gland

Neuropeptide regulation of secretion and inflammation in human airway gland serous cells

DB McMahon, RM Carey, MA Kohanski… - … Respiratory Journal, 2020 - Eur Respiratory Soc
Airway submucosal gland serous cells are sites of … defects in CFTR-dependent serous
secretion contribute to CF … Gland acini are likely significant contributors of cytokines [54]…

Secretory cells dominate airway CFTR expression and function in human airway superficial epithelia

K Okuda, H Dang, Y Kobayashi, G Carraro… - … journal of respiratory …, 2021 - atsjournals.org
… in the regulation of airway epithelial Cl − and fluid secretory rates. … Airway submucosal
glands from cystic fibrosis swine suffer from abnormal ion transport across the serous acini

Cellular and molecular architecture of submucosal glands in wild-type and cystic fibrosis pigs

W Yu, TO Moninger, AL Thurman… - Proceedings of the …, 2022 - National Acad Sciences
… SMGs secrete liquid and most of the mucus in large airways; the … To better understand the
potential role of the two acinar cell types in electrolyte and liquid secretion, we also curated a …

Early studies of airway submucosal glands

JH Widdicombe - … Journal of Physiology-Lung Cellular and …, 2019 - journals.physiology.org
Acinar origin of CFTR-dependent airway submucosal gland fluid secretion. Am J Physiol
Lung Cell Mol Physiol 292: L304–L311, 2007. doi:10.1152/ajplung.00286.2006. …

PAR-2-activated secretion by airway gland serous cells: role for CFTR and inhibition by Pseudomonas aeruginosa

DB McMahon, RM Carey… - … of Physiology-Lung …, 2021 - journals.physiology.org
… of synergistic CFTR-dependent PAR-2/VIPR secretion may … structure of an airway submucosal
gland, showing cystic … at the distal acini, which have been demonstrated to be the origin of …

[HTML][HTML] CFTR-rich ionocytes mediate chloride absorption across airway epithelia

L Lei, S Traore, GSR Ibarra, PH Karp… - The Journal of …, 2023 - Am Soc Clin Investig
… -airway epithelia and submucosal glands, thus determining … absorption and CFTR-dependent
liquid secretion. Our … CFTR within the acinus and ducts of the airway epithelium could …

Glandular proteome identifies antiprotease cystatin C as a critical modulator of airway hydration and clearance

TIA Evans, NS Joo, NW Keiser, Z Yan… - … Journal of Respiratory …, 2016 - atsjournals.org
… in CF and non-CF submucosal gland fluid droplets and found that … CFTR-dependent fluid
secretion and ENaC-dependent fluidgland with CFTR expressed in both the distal acinar and …

[HTML][HTML] Cystic fibrosis of the pancreas: the role of CFTR channel in the regulation of intracellular Ca2+ signaling and mitochondrial function in the exocrine pancreas

T Madácsy, P Pallagi, J Maleth - Frontiers in Physiology, 2018 - frontiersin.org
… within a molecular complex in airway epithelial cells, which is … I, seems to be CFTR-dependent.
The gene expression is … , the destruction of acini, pancreatic cyst formation and lastly, …