… Under several circumstances, NF-κB is activated to enable … the structure and evolution of
this fascinating pathway, we sought … show that NF-κB signaling is well conserved from oyster to …

… aberrant NIK-IKKα and/or non-canonical NF-κB signalling. … -canonical NF-κB pathway
activation [20] whereas double mutants … ) following the KD, and conserved buried residues in this …

… discuss the activation and function of NF-κB in association … (NIK), which activates and
functionally cooperates with IKKα to … Activation by IKK alpha of a second, evolutionary conserved, …

… Many evolutionarily conserved receptors can elicit downstream signals to activate NF-κB …
In vertebrates, activation of NF-κB generally happens in one of two ways. In the canonical …

… NF-κB activation occurs via two major signalling pathways: … activation of the canonical NF-κB
pathway, the activation of … the Aire gene contains a conserved non-coding sequence that …

… factor is well conserved among Kingdom Animalia, which has … It is evolutionary conserved
and present in animals ranging … are two main signaling pathways that can activate NF-κB in …

… There are two pathways for NF-kB activation, as the … A key function of NF-κB is controlling
the immune response at … shown that, double-serine phosphorylation in the conserved IkB …

… -ĸB signaling pathway is evolutionarily conserved from flies … c-Src/p38/NF-κB signaling
pathway to promote angiogenesis in the … induces activation of downstream signaling pathways, …

… pathways bifurcate to activate NF-κB and IRF family members. … NF-κB activation occurs through
one of two distinct pathways, … The conservation of the TIR domain throughout evolution as …

… A second evolutionary conserved pathway towards the activation of NF-κB has also been …
This USP6 dependent activation of NF-κB requires IKKα, IKKβ and NEMO in order for p65 …