Targeting ERK1/2 protein-serine/threonine kinases in human cancers

R Roskoski Jr - Pharmacological research, 2019 - Elsevier
… To activate downstream members of the MAP kinase module, Ras-GTP stimulates the …
protein-serine/threonine protein kinases that catalyze the phosphorylation and activation of …

Targeting c-FOS and DUSP1 abrogates intrinsic resistance to tyrosine-kinase inhibitor therapy in BCR-ABL-induced leukemia

M Kesarwani, Z Kincaid, A Gomaa, E Huber… - Nature medicine, 2017 - nature.com
kinase 3 ligand (FLT3L) and granulocyte colony-stimulating … and after BCI injection,
and measured the levels of phospho-… 3-kinase (PI3K)–AKT serine/threonine kinase 1 (AKT1); …

c-Fos protein transport into the nucleus

P Roux, S Carillo, JM Blanchard… - The FOS and JUN …, 2017 - taylorfrancis.com
… Finally, pricking of cells can also stimulate c-Fos protein … , have shown that the serine/threonine
kinase encoded by the c-… , as agonists in the phosphorylation of a stable pp33/ppl5 …

Protein kinase C γ contributes to central sensitization in a rat model of chronic migraine

B Wu, S Wang, G Qin, J Xie, G Tan, J Zhou… - Journal of Molecular …, 2017 - Springer
… CGRP and c-Fos. In addition, inhibition of PKCγ reduced the … phospholipid-dependent
serine/threonine kinases, has been … to mechanical stimulation were decreased after CM. But our …

Stimulation of B-Raf increases c-Jun and c-Fos expression and upregulates AP-1-regulated gene transcription in insulinoma cells

DS Langfermann, OG Rössler, G Thiel - Molecular and cellular …, 2018 - Elsevier
… Here, we show that stimulation of B-Raf strongly activated … -Raf, are cytosolic serine/threonine
protein kinases with a high … 1 is phosphorylated by MAP kinases and regulates c-Fos gene …

[HTML][HTML] Quantitative phosphoproteomics reveals ectopic ATP synthase on mesenchymal stem cells to promote tumor progression via ERK/c-Fos pathway activation

YW Chang, CC Wang, CF Yin, CH Wu… - Molecular & Cellular …, 2022 - ASBMB
… sites are identified in lung cancer cells stimulated with MSC-… to trigger the ERK/phospho-c-Fos-S374
pathway, which is … via activation of the ERK/phospho-c-Fos-S374 pathway. …

[HTML][HTML] Increase of c-FOS promoter transcriptional activity by the dual leucine zipper kinase

KA Köster, J Duque Escobar, A Fietkau… - Naunyn-schmiedeberg's …, 2023 - Springer
… increased c-FOS promoter activity but decreased stimulatedPhosphorylation on serine/threonine
and tyrosine residues … of DLK on c-FOS promoter activity: activation of basal activity …

LukS-PV induces differentiation by activating the ERK signaling pathway and c-JUN/c-FOS in human acute myeloid leukemia cells

C Dai, C Zhang, X Sun, Q Pan, J Peng, J Shen… - The International Journal …, 2016 - Elsevier
… , protein-serine/threonine kinases involved in intracellular cell … -PV also increased the
phosphorylation of c-FOS and c-JUN in … and c-JUN during the differentiation process stimulated by …

Involvement of phosphorylation and dephosphorylation in the control of AP-1 activity

PE Shaw, H Gille - The Fos and Jun families of transcription …, 2017 - taylorfrancis.com
… tranн scription factors implicated in c-fos promoter function, will … the c-fos gene after serum
stimulation. Instead, two waves of … open is how serine/threonine phosphorylation results in the …

The serine/threonine protein phosphatase 2A controls autoimmunity

A Sharabi, IR Kasper, GC Tsokos - Clinical Immunology, 2018 - Elsevier
… its binding to the IL-2 and c-fos promoters. As a result, the … of MEK and ERK upon T cell
activation, which results in … by Tyr307-phosphorylation in response to TCR stimulation. …