Very early lineage-specific chimerism after reduced intensity stem cell transplantation is highly predictive of clinical outcome for patients with myeloid disease
FAM Kinsella, CF Inman, A Gudger, YT Chan… - Leukemia research, 2019 - Elsevier
… Grades 2–4 acute GvHD and chronic GvHD were also … on whole blood derived PBMC and
on purified CD3 + T-cell … who exhibited full donor chimerism in T cells and mixed chimerism in …
on purified CD3 + T-cell … who exhibited full donor chimerism in T cells and mixed chimerism in …
… T-cell chimerism at 3 months followed by donor lymphocyte infusion is independently associated with favorable outcomes in alemtuzumab-based reduced-intensity …
G McIlroy, E Nikolousis, N Abou-Zeid… - Leukemia & …, 2020 - Taylor & Francis
… for 100 patients, and CD3+ T-cell compartment results were … a strong association between
acute GVHD occurrence and … 3-month FC in whole marrow was predictive of better RFS and …
acute GVHD occurrence and … 3-month FC in whole marrow was predictive of better RFS and …
Risk factors for graft-versus-host-disease after donor lymphocyte infusion following T-cell depleted allogeneic stem cell transplantation
EAS Koster, PA von dem Borne, P Van Balen… - Frontiers in …, 2024 - frontiersin.org
… the clearest indicator for induction of alloreactivity after DLI, … signs of GvHD based on the
anticipated risk of severe GvHD. … in other clinical settings, since BM chimerism, ALC and viral …
anticipated risk of severe GvHD. … in other clinical settings, since BM chimerism, ALC and viral …
Quantitative chimerism in CD3-negative mononuclear cells predicts prognosis in acute myeloid leukemia patients after hematopoietic stem cell transplantation
A Bouvier, J Riou, S Thépot, A Sutra Del Galy… - Leukemia, 2020 - nature.com
… (MAC), reduced toxicity myeloablative (RTC), reduced intensity … on two successive points
is a strong predictive factor of … occurring on donor cells cannot be detected by chimerism, as …
is a strong predictive factor of … occurring on donor cells cannot be detected by chimerism, as …
[HTML][HTML] Early mixed lymphoid donor/host chimerism is associated with improved transplant outcome in patients with primary or secondary myelofibrosis
HJ Deeg, RB Salit, T Monahan, G Schoch… - Biology of Blood and …, 2020 - Elsevier
… Except for acute GVHD, this analysis was based on the most … A time-dependent indicator
variable was used to define … , might suggest the possibility of titrating the amount of donor T cells …
variable was used to define … , might suggest the possibility of titrating the amount of donor T cells …
Pre-transplant donor CD4− invariant NKT cell expansion capacity predicts the occurrence of acute graft-versus-host disease
MT Rubio, M Bouillié, N Bouazza, T Coman… - Leukemia, 2017 - nature.com
… cells were stained and at least 5 × 10 4 CD3 + T cells with a … iNKT cells in predicting the
occurrence of grade II-IV acute GVHD … -identical sibling donors without in vivo T cell depletion, 25 …
occurrence of grade II-IV acute GVHD … -identical sibling donors without in vivo T cell depletion, 25 …
Peripheral Blood CD34 Donor Chimerism has Greater Clinical Utility Than CD3 for Detecting Relapse after Allogeneic Stem Cell Transplantation for Acute Myeloid …
TP Das, D North, SA Fleming, JLC Tan, A Ivey… - … and Cellular Therapy, 2023 - Elsevier
… risk of triggering severe GVHD after DLI [19]. Chimerism was monitored 4 weeks after AZA or
… To determine whether CD3 + DC added any value to CD34 + DC for predicting relapse, we …
… To determine whether CD3 + DC added any value to CD34 + DC for predicting relapse, we …
The predictive value of T-cell chimerism for disease relapse after allogeneic hematopoietic stem cell transplantation
Z Li, J Wang, L Deng, X Liu, F Kong, Y Zhao… - Frontiers in …, 2024 - frontiersin.org
… to verify the predictive value of donor chimerism. In the present … between T-cell chimerism,
PB chimerism, and BM chimerism … Quantitative chimerism in CD3-negative mononuclear cells …
PB chimerism, and BM chimerism … Quantitative chimerism in CD3-negative mononuclear cells …
[HTML][HTML] … Graft-versus-Host Disease Prophylaxis, and Lower CD3+ T Cell Doses Equalize Rates of Acute and Chronic Graft-versus-Host Disease in Pediatric Patients …
SH Lum, B James, G Ottaviano, AM Ewins… - … and Cellular Therapy, 2024 - Elsevier
… predictors of grade II-IV aGVHD. When considering … a potential strategy to reduce the
risk of severe GVHD in pediatric … impact on graft failure and donor chimerism. There was no …
risk of severe GVHD in pediatric … impact on graft failure and donor chimerism. There was no …
Early CD8+-recovery independently predicts low probability of disease relapse but also associates with severe GVHD after allogeneic HSCT
J Ranti, S Kurki, U Salmenniemi, M Putkonen… - PLoS …, 2018 - journals.plos.org
… Preemptive treatment was guided by MRD and/or chimerism … decreased relapse risk and
the early recovery of CD3 + - and … is a powerful predictive factor of forthcoming relapse after an …
the early recovery of CD3 + - and … is a powerful predictive factor of forthcoming relapse after an …