Theoretical frameworks and mechanistic aspects of alcohol addiction: alcohol addiction as a reward deficit/stress surfeit disorder
GF Koob, L Vendruscolo - 2023 - Springer
… behavioral impairments that afflict individuals with addiction. Clinically, the occasional but
… substance use disorders (drug addiction), is a reward deficit/stress surfeit disorder, and the …
… substance use disorders (drug addiction), is a reward deficit/stress surfeit disorder, and the …
Neurobiology of addiction: a neurocircuitry analysis
GF Koob, ND Volkow - The Lancet Psychiatry, 2016 - thelancet.com
… Drug addiction represents a dramatic dysregulation of motivational circuits that is … reward
deficits and stress surfeits, and compromised executive function in three stages. The rewarding …
deficits and stress surfeits, and compromised executive function in three stages. The rewarding …
Neuroclinical framework for the role of stress in addiction
LE Kwako, GF Koob - Chronic Stress, 2017 - journals.sagepub.com
… reward deficit neurotransmission and reversing stress surfeit neurotransmission can block the
elevation of reward … stage of the addiction cycle is engagement of the brain stress systems, …
elevation of reward … stage of the addiction cycle is engagement of the brain stress systems, …
Combining stress and dopamine based models of addiction: Towards a psycho-neuro-endocrinological theory of addiction
JH Johnston, D EJ Linden… - Current Drug Abuse …, 2016 - ingentaconnect.com
… As mentioned previously, stress excites increased dopaminergic activity in cue reactivity (of …
phases of addiction (stress surfeit and dopamine deficit - the neural markers of allostasis). …
phases of addiction (stress surfeit and dopamine deficit - the neural markers of allostasis). …
Interaction between stress and addiction: Contributions from Latin-American neuroscience
… system leads to its dysfunction and to hyperactivation of the brain’s stress response (anti-reward),
resulting in an increase in reward thresholds (reward deficit and stress surfeit). Stress …
resulting in an increase in reward thresholds (reward deficit and stress surfeit). Stress …
Stress and addictive disorders
… numerous stress events and examines how stress alters addictive behaviors. Moreover,
novel interventions were developed to alleviate stress-induced PTSD symptoms and addictive …
novel interventions were developed to alleviate stress-induced PTSD symptoms and addictive …
The role of stress in drug addiction. An integrative review
P Ruisoto, I Contador - Physiology & behavior, 2019 - Elsevier
… Not surprisingly, drug addiction has been conceptualised as a learning disorder, a reward
deficit disorder or anti-reward excess disorder, an executive function disorder, and more …
deficit disorder or anti-reward excess disorder, an executive function disorder, and more …
Neurological correlates of brain reward circuitry linked to opioid use disorder (OUD): Do homo sapiens acquire or have a reward deficiency syndrome?
… “addiction” definition from the American Society of Addiction … addiction is indeed, a brain
disorder is changing the face of … comparison of dopamine surfeit to dopamine deficit theories. …
disorder is changing the face of … comparison of dopamine surfeit to dopamine deficit theories. …
Drug addiction: a curable mental disorder?
… to treat drug addiction. We conclude that, although drug addiction is a complex disorder
that … and psychological processes, this mental disorder is treatable and may be curable by …
that … and psychological processes, this mental disorder is treatable and may be curable by …
Addiction, stress, and relational disorder: A neuro-informed approach to intervention
… Our hope is that reconceptualizing addiction as relational disorder will assist clinicians in
thinking differently about their clients and about how they might work to rebuild this relational …
thinking differently about their clients and about how they might work to rebuild this relational …