… Adeno-associated virus (AAV)-mediated gene transfer is an … normal and damaged adult and
neonatal mouse utricles, which … , dual-AAV vectors with multiple target genes may be used. …

… The homozygous mice were bred together based on their normal fertility. The WT C57BL/6J …
) system with primers and probes targeting the promoter sequences of the transgene …

… , such as noise trauma, … target cells, making AAV serotypes valuable cell-targeting research
tools [34]. Recently, a publication has summarized AAV capsid transduction into the mouse …

… Gene therapy targeting these genes could potentially benefit … However, the facial nerve
covering the utricle region makes this … The safety and effectiveness of gene therapy in mouse …

… finding that recombinant adeno-associated virus (… target for inner ear gene transfer and
shares equal vasculature with the cochlea. We investigated transgene expression in the utricle …

… gene transfer in the inner ear have used adeno-associated … epithelia of the saccule, utricle
and semicircular canals. This … Since the IHCs seemed to be the major target of the virus, we …

… , resulting in surgical trauma and postoperative hearing damage for these aforementioned
routes. … In utricle, AAV8 showed no transduction signal and AAV9 targeted scattered VHCs, in …

… need to develop gene therapy delivery strategies that target the … The most common
delivery technique is via the round … of the sensory epithelia of the utricle and the CA of lateral …

… used adeno-associated virus (AAV) for gene delivery. AAV is … mouse utricles in vivo (Fig. 3,
Supplementary Table 1). The … as the targeted cell type in inner ear gene therapy studies, the …

… affects hair cell regeneration, we cultured adult mouse utricle, lesioned hair cells with the …
Adeno-associated virus-mediated gene transfer targeting normal and traumatized mouse utricle…