[HTML][HTML] Fetal gene therapy and pharmacotherapy to treat congenital hearing loss and vestibular dysfunction

ML Hastings, JV Brigande - Hearing research, 2020 - Elsevier
mouse is not the exclusive purview of virus-mediated gene … The cristae of the semicircular
canals and the utricular and … Adeno-associated viral vectors are of particular value owing to the …

Cellular origin and response of flat epithelium in the vestibular end organs of mice to Atoh1 overexpression

L He, JY Guo, TF Qu, W Wei, K Liu, Z Peng, GP Wang… - Hearing Research, 2020 - Elsevier
… FE was mediated by an adeno-associated virus serotype 8 (… and will facilitate studies of gene
therapy for vestibular FE. … in the utricular FE, we captured images of the whole utricle using …

Gene Therapy for Congenital Hearing Loss

A Timashpolsky, SR Chorney, RC O'Reilly - Current Otorhinolaryngology …, 2022 - Springer
… , lateral and superior semicircular canals, utricle, and saccule). … Adeno-associated virus
(AAV) has emerged as the most … target DNA with only 20 bp of guide RNA (gRNA) and is able to …

Inner ear gene therapies take off: current promises and future challenges

S Delmaghani, A El-Amraoui - Journal of clinical medicine, 2020 - mdpi.com
… associated with in vivo gene therapy targeting the human inner … Finally, viral injection into
the neonatal mouse utricle leads to … Table S3: Adeno-associated virus (AAV) vectors used in …

Canalostomy as a surgical approach to local drug delivery into the inner ears of adult and neonatal mice

JY Guo, L He, TF Qu, YY Liu, K Liu, GP Wang… - JoVE (Journal of …, 2018 - jove.com
… As indicated by fast-green dye and adeno-associated virus … is potentially an ideal target for
local drug delivery; it is filled … the lesioned utricle, which was useful for gene therapy studies in …

Inner ear gene delivery: vectors and routes

C Valentini, B Szeto, JW Kysar… - Hearing, balance and …, 2020 - Taylor & Francis
… for hearing loss with a focus on vectors that target the cochlea and … Adeno-associated virus
(AAV) was the viral vector used … However, these methods are traumatic and unlikely to be the …

Mechanosensory Transduction Contributes to the Development and Maintenance of Cochlear and Vestibular Synapses

J Lee - 2021 - search.proquest.com
… Utilizing the novel gene therapy strategy, I find recovery of … Utricle injection method To
identify vectors and delivery … two delivery methods and three synthetic adeno-associated viral …

Gene therapy: an emerging therapy for hair cells regeneration in the cochlea

J Wang, J Zheng, H Wang, H He, S Li… - Frontiers in …, 2023 - frontiersin.org
… were produced at the original site of cochlear trauma. Hearing was restored to some extent
in … as a new target for the regeneration of HCs using gene therapy. In mice with Foxg1 was …

Stem cell-based hair cell regeneration and therapy in the inner ear

J Qi, W Huang, Y Lu, X Yang, Y Zhou, T Chen… - Neuroscience …, 2024 - Springer
… mediated by adeno-associated virus (AAV) have been … overcome the proliferative quiescence
in utricular supporting cells [63], … molecule drugs and virus-mediated gene regulation are …

Gene therapy as a possible option to treat hereditary hearing loss

M Morgan, JW Schott, A Rossi, C Landgraf… - Medizinische …, 2020 - degruyter.com
… adenoviral (AdV) vectors, adeno-associated viral (AAV) vectors … as a major target for gene
therapy since the successful … the RWM or injected into the utricle in neonatal animals. Analysis …