… as ovarian cells, knock-in of mutated, constitutively-active … activity of PTEN is highly
controversial; however, PTEN could … -κB)/B-cell lymphoma-extra-large (Bcl-xL)/B-cell lymphoma 2 …

… leukemia in children 21 and the same was observed in adult T… constitutively activated
AKT or using shRNA to knock down … -dependent leukemic cells may have lost PTEN activity, …

… lines bearing different PTEN status, and we found constitutive … of STAT5 activity. Thus, we
investigated BCL2 expression in … Moreover, our results show that PTEN-mutated T-ALLs do not …

… in children and adults. ALL is a malignant neoplasm of early … phosphorylation levels of PTEN
in T and B-cell lines. Nalm-6, … PI3K/Akt signaling activity by regarding PTEN and P53 as two …

… role for PTEN in pre-B acute lymphoblastic leukemia (ALL), … that PTEN promoter regions are
hypermethylated in B cell … transduced pre-B ALL cells with constitutively active (CA) forms of …

… miRs that show aberrant expression levels in Pten-deficient … we studied have constitutively
activated PI3K activity. Two of … subset of adult T-cell acute lymphoblastic leukemia with myeloid…

… Constitutive deletion of Pax5 in mice failed to produce … via PTEN inhibition to stimulate follicular
B cell proliferation (22). … constitutively active kinase activity, to drive leukemogenesis (63). …

… to their strong pro-apoptotic activity to leukemic cells. Early response to … activated (phosphorylated)
Akt with a concomitant PTEN … in untreated lymphoblasts which indicated a constitutive …

… the generation of functional mature B cells. One of these … SYK, we examined the activity of
these signaling molecules after … transfected RCH-ACV cells with a constitutively active form of …

… Finally, we show that B cell–targeted overexpression of PTEN without other confounding …
, constitutively active PI3K into our experimental system, reasoning that its activity should …