… responses, where the B cell depends on signals from helper T … the integration of signals
received by the B cell including via … may facilitate antigen encounter and affinity discrimination. …

… associated with B cell activation and fate decisions, as well … , how is antigen affinity coupled
to BCR signaling and to antigen … Thus, the BCR’s affinity for antigen not only determines the …

… of antigen access into secondary lymphoid organs, antigen … of B cell anergy that have
significantly lower Ig-Tg affinity to self-… signals and T cell help, another factor that determines B cell …

… antigen plays a crucial role in B cell activation, and in particular during affinity-maturation,
the process during which high-affinity B … Although the signaling mechanism has not yet been …

… a series of cell fate decisions for which in vivo BCR signaling … endogenous antigen recognition,
favoring MZ B cell fate and … to determine whether skewed development of B cell lineages …

… major routes for memory B cell and high-affinity long-lived plasma … Recent research has
aimed to determine whether BCR affinity has … They found that an affinity-based CD40 signal was …

… We also present our approach to identify rare antigen-specific … targeting model antigens and
of B cell signaling have also … unrelated antigens with physiologically relevant affinities. The …

… B cell precursor frequency, B cell receptor affinity for antigen, … B cells with higher p:MHC
receive more T FH help signals … frequency, affinity, and avidity in determining B cell outcomes (…

… ], thus receiving survival signals via BCR binding. … determined by the affinity of the BCR for
antigen, determines the level of IRF4 induction. This, in turn, determines whether the GC B cell …

… , a signal transduction molecule expressed throughout B-cell … the fate of the GC B cell, it is
essential for affinity maturation of … of the complementarity-determining regions (CDRs; Chapter …