… of insulin dysfunction in 7 and 23 months 3xTg-AD mice, that … the age-specific consequences
of insulin deficiency on AD … To investigate insulin dysfunction in a murine model exhibiting …

… We found that 3xTg-AD mice display impaired glucose tolerance as early as 1 month of age,
concomitant with a … -like neuropathology and cognitive deficits in the 3xTg-AD mouse model. …

… Our 3xTg-AD model may be a model of “accelerated aging,” in which case our … mice exhibit
increased weight gain and glucose intolerance on HF diet compared to males in middle age (…

… Sex and age interact to influence glucose intolerance in 3xTg-AD … results of the glucose
tolerance test in 3xTg-AD male and female mice at A 3, B 6, C 9, and D 12 months of age. E Area …

… performance on the glucose tolerance test that was significant at the 15 minute time point.
In … of AD-related pathology in AD transgenic mice. In the 3xTg-AD mouse model of AD, …

… pathologies such as Alzheimer's disease (AD). This is the case … glucose intolerance and
path length found in 3xTg-AD … at this age (see below), which, we hypothesize, may be related to …

… in both mouse models, with 3xTg-AD mice showing more … and impaired glucose clearance
in the glucose tolerance test (… metabolism is normal in 3xTg-AD mice at 10 months of age …

… have beneficial effects in the 3xTg-AD model, there is no … examine these interventions
in additional animal models as well as the … As age increases, so does susceptibility to age-related …

… impairment (weight gain, visceral fat, and glucose intolerance) in female compared to male
3xTg-AD mice [… In order to create a mouse model of MxD, 3xTg-AD mice (~ 3 months of age) …

… in the brains of an AD mouse model. In particular, we studied … 3xTg-AD mice, a mouse AD
model harboring two familial AD-… ) gene, age-dependent glucose intolerance and pancreatic …