Impaired thermoregulation and beneficial effects of thermoneutrality in the 3× Tg-AD model of Alzheimer's disease
… the triple-transgenic mouse model of AD (3×Tg-AD) spontaneously develops a lower basal
body temperature and is … The 3×Tg-AD mouse model of AD displays an age-related deficit in …
body temperature and is … The 3×Tg-AD mouse model of AD displays an age-related deficit in …
Metabolic determinants of Alzheimer's disease: A focus on thermoregulation
M Tournissac, M Leclerc, J Valentin-Escalera… - Ageing Research …, 2021 - Elsevier
… Alzheimer’s disease (AD) is a complex age-related neurodegenerative … and maintenance
of body temperature. In recent years, the modulation of BAT activity has been increasingly …
of body temperature. In recent years, the modulation of BAT activity has been increasingly …
Abnormal circadian locomotor rhythms and Per gene expression in six-month-old triple transgenic mice model of Alzheimer's disease
M Wu, F Zhou, X Cao, J Yang, Y Bai, X Yan, J Cao… - Neuroscience …, 2018 - Elsevier
… Recently, Musiek et al. reported that men are more susceptible to age-related … activity was
related to the body weight difference [5], our results did not find significant difference of body …
related to the body weight difference [5], our results did not find significant difference of body …
Alterations of clock gene RNA expression in brain regions of a triple transgenic model of Alzheimer's disease
… to the core of the SCN [4], which responds to light/dark cycles and co-ordinates circadian
function, including locomotor activity, hormone secretion, body temperature … that the age-related …
function, including locomotor activity, hormone secretion, body temperature … that the age-related …
Metabolic changes over the course of aging in a mouse model of tau deposition
A Joly-Amado, KS Serraneau, M Brownlow… - Neurobiology of …, 2016 - Elsevier
… energy expenditure in addition to locomotor activity in a mouse model of … These age-related
differences in body weight were … in the triple-transgenic Alzheimer's disease mouse model …
differences in body weight were … in the triple-transgenic Alzheimer's disease mouse model …
… -dependent changes in the glutamate-nitric oxide pathway in the hippocampus of the triple transgenic model of Alzheimer's disease: implications for neurometabolic …
C Dias, CF Lourenço, E Ferreiro, RM Barbosa… - Neurobiology of …, 2016 - Elsevier
… Here we used a transgenic mouse model of AD to explore AD- and age-related alterations in
… particularly attractive in the context of plasticity by combining synaptic activity with changes …
… particularly attractive in the context of plasticity by combining synaptic activity with changes …
[HTML][HTML] Changes in 24 h rhythmicity of spontaneous locomotor activity in the triple transgenic mouse for Alzheimer's disease (3xTg-AD) in a jet lag protocol …
…, E Arnold, S Díaz-Cintra… - Journal of Circadian …, 2021 - ncbi.nlm.nih.gov
… locomotor activity, increased body temperature, and increased food intake [21]. Also, changes
in … wheel alleviated some age-related changes in the circadian system like changes in the …
in … wheel alleviated some age-related changes in the circadian system like changes in the …
[HTML][HTML] Age related changes in muscle mass and force generation in the triple transgenic (3xTgAD) mouse model of Alzheimer's disease
… Alzheimer’s disease (AD) may show accelerated sarcopenia phenotypes. To investigate
whether pathological changes … of age, we used the triple transgenic mouse model of AD (…
whether pathological changes … of age, we used the triple transgenic mouse model of AD (…
Repurposing beta-3 adrenergic receptor agonists for Alzheimer's disease: beneficial effects in a mouse model
M Tournissac, TM Vu, N Vrabic, C Hozer… - Alzheimer's Research & …, 2021 - Springer
… , with frequent age-related comorbidities, multi-… the triple transgenic (3xTg-AD) mice [8,9,10,11].
Studies in mouse and hibernators repeatedly showed that decreased body temperature …
Studies in mouse and hibernators repeatedly showed that decreased body temperature …
Disruption of metabolic, sleep, and sensorimotor functional outcomes in a female transgenic mouse model of Alzheimer's disease
DC Nwafor, S Chakraborty, S Jun, AL Brichacek… - Behavioural brain …, 2021 - Elsevier
… The objective of this study was to elucidate the extent to which metabolic activity, sleep-wake
cycle, and sensorimotor function is impaired in APPSwDI/Nos2 −/− (CVN-AD) transgenic …
cycle, and sensorimotor function is impaired in APPSwDI/Nos2 −/− (CVN-AD) transgenic …