Bacterial load and related innate immune response in the bronchi of rapid decliners with chronic obstructive pulmonary disease

SE D'Anna, F Dossena, I Gnemmi, P Brun… - Respiratory …, 2023 - Elsevier
… and compare the bronchial bacterial load related to cell … in bronchial biopsies of stable COPD
patients with rapid vs slow vs no … We defined rapid decline as rate of FEV1 decline >70 ml/…

Chronic bronchial infection is associated with more rapid lung function decline in chronic obstructive pulmonary disease

MÁ Martínez-García, R Faner, G Oscullo… - Annals of the …, 2022 - atsjournals.org
… cohort follow-up, and we did not quantify bacterial load but used instead a cut-off point of …
Airway bacterial load and FEV 1 decline in patients with chronic obstructive pulmonary disease

Airway mucin 2 is decreased in patients with severe chronic obstructive pulmonary disease with bacterial colonization

O Sibila, L Garcia-Bellmunt, J Giner… - Annals of the …, 2016 - atsjournals.org
… , a polymorphism of the MUC5B gene has been associated with increased airway bacterial
burden and risk of … Association of chronic mucus hypersecretion with FEV 1 decline and …

Airway dysbiosis accelerates lung function decline in chronic obstructive pulmonary disease

W Liang, Y Yang, S Gong, M Wei, Y Ma, R Feng… - Cell host & …, 2023 - cell.com
… Progressive lung function decline is a hallmark of chronic obstructive pulmonary disease (…
UK centers, that baseline airway dysbiosis in COPD patients, characterized by the enrichment …

Community dynamics and the lower airway microbiota in stable chronic obstructive pulmonary disease, smokers and healthy non-smokers

GG Einarsson, DM Comer, L McIlreavey, J Parkhill… - Thorax, 2016 - thorax.bmj.com
… . Airway bacterial load and FEV1 decline in patients with chronic obstructive pulmonary
disease. Am J Respir Crit Care Med 2003;167:1090–5. doi:10.1164/rccm.200210-…

[HTML][HTML] The relationship between airway inflammation and exacerbation in chronic obstructive pulmonary disease

DW Perng, PK Chen - Tuberculosis and respiratory diseases, 2017 - synapse.koreamed.org
… In stable COPD patients, FEV1 showed a significant inverse … total bacterial count, and bacterial
load in the airways was … detection of GERD, reduction of bacterial load in bronchiectasis, …

Bacterial load and inflammatory response in sputum of alpha-1 antitrypsin deficiency patients with COPD

B Balbi, C Sangiorgi, I Gnemmi, I Ferrarotti… - … of Chronic Obstructive …, 2019 - Taylor & Francis
… A pathogenic role of bacterial load leading to bronchial … to decline in absolute numbers in
AATD-AT patients compared … a reduction in neutrophil accumulation in the lower airways and …

[HTML][HTML] Relationship between gut microbiota and lung function decline in patients with chronic obstructive pulmonary disease: a 1-year follow-up study

YC Chiu, SW Lee, CW Liu, TY Lan, LSH Wu - Respiratory Research, 2022 - Springer
bacterial richness and diversity in stool samples changed significantly when the FEV 1 declined
more than 40 ml/year (decline … control (Bacteroidetes) and decline (Firmicutes) groups. …

Bacterial and viral infections and related inflammatory responses in chronic obstructive pulmonary disease

SE D'Anna, M Maniscalco, F Cappello… - Annals of …, 2021 - Taylor & Francis
… of bacteria and the microbiota composition in COPD airways … the airwaysbacterial load and
the bronchial inflammation has … in COPD patientsairways further contributes to reduction of …

[HTML][HTML] A systematic review and meta-analysis of the prevalence and impact of pulmonary bacterial colonisation in stable state chronic obstructive pulmonary disease …

MN Armitage, DA Spittle, AM Turner - Biomedicines, 2021 - mdpi.com
… Data on bacterial load in positive cultures were sparingly … FEV1 data were reported across
most studies as mean FEV1 (… in airways disease, such as aspergillus, are not bacteria and …