Dioscin ameliorates cardiac hypertrophy through inhibition of the MAPK and Akt/GSK3β/mTOR pathways
L Chen, Q Li, L Lei, T Li - Life Sciences, 2018 - Elsevier
… protected the heart from cardiac hypertrophy in vivo, we next … AngII-induced activation of
hallmarks of the MAPK and AKT/… -induced hypertrophy, we need to overexpress the full-length or …
hallmarks of the MAPK and AKT/… -induced hypertrophy, we need to overexpress the full-length or …
The IGF1-PI3K-Akt signaling pathway in mediating exercise-induced cardiac hypertrophy and protection
KL Weeks, BC Bernardo, JYY Ooi, NL Patterson… - … disease prevention and …, 2017 - Springer
… ; stiffens the heart and impairs cardiac contraction) and inadequate … (nuclear-targeted Akt)
had normal heart size and function … has not been reported in vivo. However, delivery of human …
had normal heart size and function … has not been reported in vivo. However, delivery of human …
Endothelial and cardiomyocyte PI3Kβ divergently regulate cardiac remodelling in response to ischaemic injury
… that Akt activation was required for VEGF-induced angiogenic … , reducing myocardial ischaemic
injury in vivo, whereas CM-… Regulation of myocardial contractility and cell size by distinct …
injury in vivo, whereas CM-… Regulation of myocardial contractility and cell size by distinct …
H-Ras Isoform Mediates Protection Against Pressure Overload–Induced Cardiac Dysfunction in Part Through Activation of AKT
T Matsuda, JI Jeong, S Ikeda, T Yamamoto… - Circulation: Heart …, 2017 - Am Heart Assoc
… , characterized by increased cell size and activation of … expression in vivo to show that
restoration of AKT function … AAV-AKT administration may increase cardiac contractility or …
restoration of AKT function … AAV-AKT administration may increase cardiac contractility or …
Ablation of Akt2 prevents paraquat-induced myocardial mitochondrial injury and contractile dysfunction: role of Nrf2
S Wang, X Zhu, L Xiong, J Ren - Toxicology Letters, 2017 - Elsevier
… for Akt in cardiac homeostasis. To this end, this study was designed to examine the role of
Akt2 in acute paraquat exposure-induced cardiac contractile and … changes in cell length during …
Akt2 in acute paraquat exposure-induced cardiac contractile and … changes in cell length during …
Wogonin attenuates isoprenaline-induced myocardial hypertrophy in mice by suppressing the PI3K/Akt pathway
W Qian, D Yu, J Zhang, Q Hu, C Tang, P Liu… - Frontiers in …, 2018 - frontiersin.org
… by wogonin in isoprenaline-induced myocardial hypertrophy in vivo and in vitro. It …
enhancement in hypertrophic development, including amplification of cell size and activation of Akt …
enhancement in hypertrophic development, including amplification of cell size and activation of Akt …
Epigallocatechin gallate (EGCG) attenuates myocardial hypertrophy and fibrosis induced by transverse aortic constriction via inhibiting the Akt/mTOR pathway
Y Cui, Y Wang, G Liu - Pharmaceutical biology, 2021 - Taylor & Francis
… volume stress and many other problems. Initially, it is adaptively against increased workload
or defects in the efficiency of contractile … and in vivo, however, chronic Akt overexpression is …
or defects in the efficiency of contractile … and in vivo, however, chronic Akt overexpression is …
… of microRNA-203 inhibits myocardial fibrosis and oxidative stress in mice with diabetic cardiomyopathy through the inhibition of PI3K/Akt signaling pathway via …
X Yang, X Li, Q Lin, Q Xu - Gene, 2019 - Elsevier
… tissues, by which DM-induced cardiac dysfunction and … , and the myocardial cells were
well-arranged, the size was … the surface area of myocardial cells significantly increased in the DM, …
well-arranged, the size was … the surface area of myocardial cells significantly increased in the DM, …
Role of PI3K/Akt signaling pathway in cardiac fibrosis
W Qin, L Cao, IY Massey - Molecular and cellular biochemistry, 2021 - Springer
… Besides, PI3Kα may regulate cardiac fibrosis via affecting the myocardial contractility since
… or rapamycin in vivo. However, the Akt inhibitors possess the ability to induce an increase in …
… or rapamycin in vivo. However, the Akt inhibitors possess the ability to induce an increase in …
Exendin-4 induces myocardial protection through MKK3 and Akt-1 in infarcted hearts
… with longer duration of effect in vivo have been explored, among … dimension (LVID) and
significant decrease in contractility … We measured the heart weight/tibia length and heart weight/…
significant decrease in contractility … We measured the heart weight/tibia length and heart weight/…