Allergic sensitization modifies the pulmonary expression of 5-hydroxytryptamine receptors in guinea pigs
There is mounting evidence that 5-hydroxytryptamine (5-HT) plays a role in asthma.
However, scarce information exists about the pulmonary expression of 5-HT receptors and
its modification after allergic sensitization. In the present work, we explored the expression of
5-HT 1A, 5-HT 2A, 5-HT 3, 5-HT 4, 5-ht 5a, 5-HT 6, and 5-HT 7 receptors in lungs from
control and sensitized guinea pigs through qPCR and Western blot. In control animals,
mRNA from all receptors was detectable in lung homogenates, especially from 5-HT 2A and …
However, scarce information exists about the pulmonary expression of 5-HT receptors and
its modification after allergic sensitization. In the present work, we explored the expression of
5-HT 1A, 5-HT 2A, 5-HT 3, 5-HT 4, 5-ht 5a, 5-HT 6, and 5-HT 7 receptors in lungs from
control and sensitized guinea pigs through qPCR and Western blot. In control animals,
mRNA from all receptors was detectable in lung homogenates, especially from 5-HT 2A and …
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