Tight junctions in the development of asthma, chronic rhinosinusitis, atopic dermatitis, eosinophilic esophagitis, and inflammatory bowel diseases

K Sugita, K Kabashima - Journal of leukocyte biology, 2020 - academic.oup.com
… that bronchial epithelial barrier leakiness in asthmaticfunction by increasing the TJ
expression. In lung and normal bronchial epithelial cells, there are commonly expressed junctional

Role of airway epithelial barrier dysfunction in pathogenesis of asthma

Y Gon, S Hashimoto - Allergology International, 2018 - jstage.jst.go.jp
… onset of allergic inflammation, disrupts the tight junction directly … A study of the tight junction
proteins in airway epithelial cells … , suggesting the potential involvement of EGFR signaling. …

The role of defective epithelial barriers in allergic lung disease and asthma development

N Noureddine, M Chalubinski… - Journal of asthma and …, 2022 - Taylor & Francis
epithelial barrier and result in the chronic inflammation seen in allergic diseases and asthma
Citation20 Gap junction proteins (GJs), connexins, which are expressed in different types of …

Epithelial barriers in allergy and asthma

PW Hellings, B Steelant - Journal of Allergy and Clinical Immunology, 2020 - Elsevier
… 2 inflammatory responses often seen in allergic asthma and … , AR, or COPD suggest a
possible role for different HDACs in … barrier function and junctional proteins in primary bronchial …

Epithelial cell dysfunction, a major driver of asthma development

IH Heijink, VNS Kuchibhotla, MP Roffel, T Maes… - Allergy, 2020 - Wiley Online Library
… with delocalization of junctional proteins (Figure 3). … inflammation associated with atopic
asthma. Both Th2 cells and ILC2 may contribute to the compromised epithelial barrier function

Tight junction, mucin, and inflammasome‐related molecules are differentially expressed in eosinophilic, mixed, and neutrophilic experimental asthma in mice

HTT Tan, S Hagner, F Ruchti, U Radzikowska, G Tan… - Allergy, 2019 - Wiley Online Library
epithelial tight junction (TJ) molecules’ expression and barrier function are impaired in asthma
… Our finding of significantly downregulated Zo-1 in all inflammatory phenotypes of AAI is in …

[HTML][HTML] Phenotypic and genetic aspects of epithelial barrier function in asthmatic patients

M Loxham, DE Davies - Journal of Allergy and Clinical Immunology, 2017 - Elsevier
junctional proteins is likely to have important implications for the maintenance and stability
of the epithelium … severe asthma than type 2 inflammation, suggesting that epithelial integrity …

Tight junctions in pulmonary epithelia during lung inflammation

OH Wittekindt - Pflügers Archiv-European Journal of Physiology, 2017 - Springer
Inflammatory lung diseases like asthma bronchiale, chronic obstructive pulmonary …
inflammation is elusive. This review emphasises the role of the tight junction of the airway epithelium

Mucosal barrier defects: what have we learned from atopic dermatitis, asthma, and allergic rhinitis?

P Smith, M Koval, JM Levy - Current Otorhinolaryngology Reports, 2020 - Springer
roles for tight junction proteins in the … allergic inflammatory mediators driving epithelial
barrier dysfunction in AR. In addition, this study describes the epithelial barrier and TJ proteins in …

Mechanisms and biomarkers of airway epithelial cell damage in asthma: A review

Y Yang, M Jia, Y Ou, IM Adcock… - The Clinical Respiratory …, 2021 - Wiley Online Library
… pathological changes in severe asthma due, in part, to activation of inflammatory and immune
… and IL-6 gene expression. Other miRNAs expressed in AEC with a potential role in asthma