Insulin signaling in health and disease
AR Saltiel - The Journal of clinical investigation, 2021 - Am Soc Clin Investig
… Activation of Akt and other protein kinases produces … the complex and allows for RalA-GTP
binding (140). Knockdown or … by decreasing transcription of FBP1 (encoding bisphosphatase) …
binding (140). Knockdown or … by decreasing transcription of FBP1 (encoding bisphosphatase) …
Translational control in virus-infected cells
N Stern-Ginossar, SR Thompson… - Cold Spring …, 2019 - cshperspectives.cshlp.org
… Composed of three subunits (α,β,γ), eIF2 is a GTP-binding … where RNA polymerase II
generates primary transcripts that … encoded by the DNA viruses EBV and KSHV also generates …
generates primary transcripts that … encoded by the DNA viruses EBV and KSHV also generates …
Molecular logic of mTORC1 signalling as a metabolic rheostat
AJ Valvezan, BD Manning - Nature metabolism, 2019 - nature.com
… to promote the splicing and maturation of SREBP-dependent transcripts encoding lipogenic
… is GTP loaded and RagC/D is GDP loaded, but, in contrast to Rheb-GTP binding, mTORC1 …
… is GTP loaded and RagC/D is GDP loaded, but, in contrast to Rheb-GTP binding, mTORC1 …
mRNA capping: biological functions and applications
… (RNA export factor, also known as Aly) of the transcription export … molecule at a GTP-binding
pocket for 2′O methylation (120). … family, encodes a heterodimeric RNA capping enzyme …
pocket for 2′O methylation (120). … family, encodes a heterodimeric RNA capping enzyme …
… Upregulations Concern Most Neurotransmission and Neuropeptide Pathways, While Downregulations Affect Prominently Itpr1, Usp2 and Non-Coding RNA
M Reichlmeir, J Canet-Pons, G Koepf, W Nurieva… - Cells, 2023 - mdpi.com
… for GO biological process (upper panel) and GO molecular … all coding transcripts, further
analyses of alternative splicing … and might therefore mimic alternative splicing artificially, we …
analyses of alternative splicing … and might therefore mimic alternative splicing artificially, we …
[图书][B] Molecular Biology of the Cell: Seventh International Student Edition with Registration Card
… in Many different Proteins the human Genome encodes a … alternative RNa Splicing Can
Produce different Forms of a … dimerization of transcription Regulators Increases their affinity …
Produce different Forms of a … dimerization of transcription Regulators Increases their affinity …
Structural fingerprints, interactions, and signaling networks of RAS family proteins beyond RAS isoforms
S Nakhaei-Rad, F Haghighi, P Nouri… - Critical reviews in …, 2018 - Taylor & Francis
… different mRNA transcripts, produced by alternative splicing … KRAS gene, which encodes
two transcripts, KRAS4A and … Unlike classical RAS proteins, these GTP binding proteins are …
two transcripts, KRAS4A and … Unlike classical RAS proteins, these GTP binding proteins are …
A (dis) integrated stress response: Genetic diseases of eIF2α regulators
… an ATF4 reporter that produces a different color fluorophore … ribosomal protein mRNAs, in
addition to transcripts encoding … Ile222Thr is located in the GTP-binding domain of eIF2γ and …
addition to transcripts encoding … Ile222Thr is located in the GTP-binding domain of eIF2γ and …
The oncogenic PI3K-induced transcriptomic landscape reveals key functions in splicing and gene expression regulation
… to activate SR proteins and affect alternative splicing (17). Dual … each transcript remained
constant. We next investigated the … This isoform is predicted to lack the GTP-binding and switch …
constant. We next investigated the … This isoform is predicted to lack the GTP-binding and switch …
[HTML][HTML] Molecular pathogenesis of long QT syndrome type 2
JL Smith, CL Anderson, DE Burgess, CS Elayi… - Journal of …, 2016 - Elsevier
… Ether-à-go-go-Related Gene or hERG) encodes the voltage-… of the Kv11.1 proteins encoded
by the normal or wild type (WT) … Alternative splicing and polyadenylation of pre-mRNA can …
by the normal or wild type (WT) … Alternative splicing and polyadenylation of pre-mRNA can …