Insulin signaling in health and disease

AR Saltiel - The Journal of clinical investigation, 2021 - Am Soc Clin Investig
… Activation of Akt and other protein kinases produces … the complex and allows for RalA-GTP
binding (140). Knockdown or … by decreasing transcription of FBP1 (encoding bisphosphatase) …

Translational control in virus-infected cells

N Stern-Ginossar, SR Thompson… - Cold Spring …, 2019 - cshperspectives.cshlp.org
… Composed of three subunits (α,β,γ), eIF2 is a GTP-binding … where RNA polymerase II
generates primary transcripts that … encoded by the DNA viruses EBV and KSHV also generates

Molecular logic of mTORC1 signalling as a metabolic rheostat

AJ Valvezan, BD Manning - Nature metabolism, 2019 - nature.com
… to promote the splicing and maturation of SREBP-dependent transcripts encoding lipogenic
… is GTP loaded and RagC/D is GDP loaded, but, in contrast to Rheb-GTP binding, mTORC1 …

mRNA capping: biological functions and applications

A Ramanathan, GB Robb, SH Chan - Nucleic acids research, 2016 - academic.oup.com
… (RNA export factor, also known as Aly) of the transcription export … molecule at a GTP-binding
pocket for 2′O methylation (120). … family, encodes a heterodimeric RNA capping enzyme …

… Upregulations Concern Most Neurotransmission and Neuropeptide Pathways, While Downregulations Affect Prominently Itpr1, Usp2 and Non-Coding RNA

M Reichlmeir, J Canet-Pons, G Koepf, W Nurieva… - Cells, 2023 - mdpi.com
… for GO biological process (upper panel) and GO molecular … all coding transcripts, further
analyses of alternative splicing … and might therefore mimic alternative splicing artificially, we …

[图书][B] Molecular Biology of the Cell: Seventh International Student Edition with Registration Card

B Alberts, R Heald, A Johnson, D Morgan, M Raff… - 2022 - books.google.com
… in Many different Proteins the human Genome encodes a … alternative RNa Splicing Can
Produce different Forms of a … dimerization of transcription Regulators Increases their affinity …

Structural fingerprints, interactions, and signaling networks of RAS family proteins beyond RAS isoforms

S Nakhaei-Rad, F Haghighi, P Nouri… - Critical reviews in …, 2018 - Taylor & Francis
different mRNA transcripts, produced by alternative splicing … KRAS gene, which encodes
two transcripts, KRAS4A and … Unlike classical RAS proteins, these GTP binding proteins are …

A (dis) integrated stress response: Genetic diseases of eIF2α regulators

AM English, KM Green, SL Moon - … Reviews: RNA, 2022 - Wiley Online Library
… an ATF4 reporter that produces a different color fluorophore … ribosomal protein mRNAs, in
addition to transcripts encoding … Ile222Thr is located in the GTP-binding domain of eIF2γ and …

The oncogenic PI3K-induced transcriptomic landscape reveals key functions in splicing and gene expression regulation

E Ladewig, F Michelini, K Jhaveri, P Castel, J Carmona… - Cancer research, 2022 - AACR
… to activate SR proteins and affect alternative splicing (17). Dual … each transcript remained
constant. We next investigated the … This isoform is predicted to lack the GTP-binding and switch …

[HTML][HTML] Molecular pathogenesis of long QT syndrome type 2

JL Smith, CL Anderson, DE Burgess, CS Elayi… - Journal of …, 2016 - Elsevier
… Ether-à-go-go-Related Gene or hERG) encodes the voltage-… of the Kv11.1 proteins encoded
by the normal or wild type (WT) … Alternative splicing and polyadenylation of pre-mRNA can …