[HTML][HTML] Potential roles of amiloride-sensitive sodium channels in cancer development

S Xu, C Liu, Y Ma, HL Ji, X Li - BioMed research international, 2016 - hindawi.com
Increasing evidence suggests that ion channels not only regulate ion … “Relative contribution
of chloride channels and transporters to regulatory volume decrease in human glioma cells,” …

Ion channels and their role in the pathophysiology of gliomas

T Takayasu, K Kurisu, Y Esquenazi… - Molecular cancer …, 2020 - AACR
Cell volume changes through the regulation of ion flux, … increased understanding of the
contributions of ion channels … form an amiloride-sensitive nonselective cation channel. The …

[HTML][HTML] Ion channels as therapeutic targets in high grade gliomas

M Griffin, R Khan, S Basu, S Smith - Cancers, 2020 - mdpi.com
sodium channels (ENaC) are a class of amiloride-sensitive … of human glioma biopsies found
that higher grade gliomas … in glioma cell division, likely because of its regulatory effect on …

[HTML][HTML] Ion channels in gliomas—from molecular basis to treatment

AF Elias, BC Lin, BJ Piggott - International Journal of Molecular Sciences, 2023 - mdpi.com
… for ASIC1 in glioma cell volume regulation in response to a … at the invadopodium of D54
human glioma cells [16,17]. Blocking … to form an amiloride-sensitive nonselective cation channel. …

[HTML][HTML] ENaC/DEG in tumor development and progression

C Liu, LL Zhu, SG Xu, HL Ji, XM Li - Journal of Cancer, 2016 - ncbi.nlm.nih.gov
… -grade human malignant glioma, immortalized human glioma cells … , or sodium 4-phenylbutyrate,
a transcriptional regulator, … of the amiloride-sensitive channel activity may reverse high-…

[PDF][PDF] Gliomas malignos expressam canais de Na+ sensíveis ao amiloride

JK Bubien, DA Keeton, CM Fuller, GY Gillespie… - medicinacomplementar.com.br
cell lines originally derived from human glioblastoma cells (… presence of amiloride-sensitive
inward Na+ currents in humanregulated ion channels; such channels may be involved in …

[HTML][HTML] Mambalgin-2 induces cell cycle arrest and apoptosis in glioma cells via interaction with ASIC1a

M Bychkov, M Shulepko, D Osmakov, Y Andreev… - Cancers, 2020 - mdpi.com
… can participate in the regulation of glioblastoma cell … the amiloride-sensitive ASIC1a channels
in glioma U251 MG … Our data suggest that mambalgin-2 inhibits the growth of glioma cells

Sodium homeostasis in the tumour microenvironment

TK Leslie, AD James, F Zaccagna, JT Grist… - … et Biophysica Acta (BBA …, 2019 - Elsevier
… to metabolism, pH regulation, vascularity and cell density that … that increases in intracellular
volume fraction can contribute to … The amiloride-sensitive epithelial Na + channel (ENaC) and …

… and Glyceraldehyde-3-Phosphate Dehydrogenase-Dependent Regulation of Epithelial Sodium Channels in hPheo1 Wild-type and SDHB Knockdown Cells

N Bala, L Yu, LP Liu, L Shelton, Y Xu… - …, 2023 - academic.oup.com
… in glioma cells (10); contribute to increased proliferation and … cancer cell behavior have
focused on changes in cell volume. … to contribute to amiloride-sensitive current in cancer cells (39)…

[HTML][HTML] Glioblastoma cancer stem cell lines express functional acid sensing ion channels ASIC1a and ASIC3

Y Tian, P Bresenitz, A Reska, L El Moussaoui… - Scientific reports, 2017 - nature.com
contribution of ASIC3 to ASIC currents in most R54 cells. In … and R8 cells have a similar
amiloride-sensitive basal current, … HGF/SF and menthol increase human glioblastoma cell