… verapamil, digoxin, and amiodarone. In this review, Pgp-mediated DDIs and their effects
on … renal clearance of quinidine at elevated doses, although digoxin’s effect on the AUC of …

… Digoxin verapamil and quinidine are substrates of P-glycoprotein and verapamil and quinidine
inhibit the clearance of digoxin … amiodarone combined with digoxin increases the digoxin …

… for arrhythmias associated with digitalis toxicity, excess … action is very similar to that of
quinidine, but it does not prolong … organ system, amiodarone treatment should be reevaluated …

… Verapamil also interacts with digoxin and may produce a … Administration of quinidine to a
patient already on digoxin leads to an … These include verapamil, amiodarone, propafenone and …

… and concomitant use of drugs like Amiodarone, Quinidine and Verapamil may affect the
Digoxin clearance. In terms of excretion, 50-70% of Digoxin is excreted unchanged by renal, …

… be exercised as certain medications, such as amiodarone, diltiazem, verapamil, and quinidine,
can elevate digoxin levels in the bloodstream. Digoxin levels are used as a good toxicity …

… digoxin when quinidine is coadministered reflects this action in vivo, particularly since the
effects of quinidine (increased digoxin … digoxin concentrations (eg, amiodarone, verapamil, …

… intoxication decreases by selecting the dose of digoxin based on blood digoxin concentrations.
As class I antiarrhythmic drugs and amiodarone cause ADRs more commonly at higher …

… are recognised P-gp substrates [6, 55]. Indeed, verapamil, quinidine, dronedarone and
amiodarone … %, while digoxin or atorvastatin had relatively minor effects on the pharmacokinetic …

… for digoxin,* fashions a molecule that competitively binds and … Diarrhea is the most common
adverse effect during quinidine … chronic amiodarone therapy—there is currently no effective …