Clinical relevance of hepatic and renal P‐gp/BCRP inhibition of drugs: An international transporter consortium perspective

KS Taskar, X Yang, S Neuhoff, M Patel… - Clinical …, 2022 - Wiley Online Library
… dataset was 178% for digoxin in the presence of quinidine. … amiodarone and spironolactone,
increasing digoxin AUC by … involved the inhibitor verapamil, increasing digoxin AUC by 41 …

[PDF][PDF] Pharmacokinetic Changes and Dosage Adjustment of Digoxin in Elderly Patients with Atrial Fibrillation: A Narrative Review

M Alfaqeeh, LI Permatasari, MA Khairinisa… - Pharmacology and …, 2023 - researchgate.net
… be exercised as certain medications, such as amiodarone, diltiazem, verapamil, and quinidine,
can elevate digoxin levels in the bloodstream. Digoxin levels are used as a good toxicity …

Renal excretion of dabigatran: the potential role of multidrug and toxin extrusion (MATE) proteins

H Shen, M Yao, M Sinz, P Marathe… - Molecular …, 2019 - ACS Publications
… ([ 3 H]digoxin, 1 μM or [ 3 H]cladribine, 1 μM) was prepared in HBSS buffer containing 10 …
of 20 μM amiodarone, verapamil, clarithromycin, ketoconazole, quinidine, or pyrimethamine in …

Edoxaban and the issue of drug-drug interactions: from pharmacology to clinical practice

A Corsini, N Ferri, M Proietti, G Boriani - Drugs, 2020 - Springer
are recognised P-gp substrates [6, 55]. Indeed, verapamil, quinidine, dronedarone and
amiodarone … %, while digoxin or atorvastatin had relatively minor effects on the pharmacokinetic …

Species difference in brain penetration of P-gp and BCRP substrates among monkey, dog and mouse

Y Kido, I Nanchi, Y Fusamae, T Matsuzaki… - Drug Metabolism and …, 2022 - Elsevier
… (cetirizine, fexofenadine, verapamil, amiodarone, digoxin, quinidine and loperamide) ranged
… Prior to this study, the brain distribution of digoxin using discrete dosing in one monkey was

ABCB1 and SLCO1B3 Gene Polymorphisms and Their Impact on Digoxin Pharmacokinetics in Atrial Fibrillation Patients among the Tunisian …

N Tounsi, I Trabelsi, E Kerkeni, MH Grissa, N Fredj… - Pharmacology, 2017 - karger.com
… with digoxin in AF patients such as amiodarone, propafenone and quinidine, which are P-…
In summary, our findings suggest that the inter-individual variation in SDC is not affected by …

Antiarrhythmic drugs: risks and benefits

P Mankad, G Kalahasty - Medical Clinics, 2019 - medical.theclinics.com
… This classification system does not include adenosine or digoxin … Because of its I To blocking
properties, quinidine has a niche … A complete discussion of the side effects of amiodarone is

Antiarrhythmic agents and torsades de pointes

SY Wass, MK Chung - Torsades de Pointes, 2022 - Elsevier
… VA who either are not candidates for or decline an ICD, quinidine or … Oral digoxin or
amiodarone may be reasonable for ongoing … , and verapamil are ineffective or contraindicated 4 …

Gut microbiota and cardiac arrhythmia: a pharmacokinetic scope

OA Nabeh - The Egyptian Heart Journal, 2022 - Springer
… ), verapamil (nor-verapamil), Quinidine (3-OH quinidine), … that the increased bioavailability
of amiodarone is due to the … P-gp transporters, digoxin level can be attenuated by GM as …

Digoxin use in cardiac amyloidosis

JP Donnelly, BW Sperry, A Gabrovsek, A Ikram… - The American Journal of …, 2020 - Elsevier
… He developed an episode of VT storm requiring 20 implantable cardioverter-defibrillator (ICD)
shocks in the context of also being quinidine and metronizadole with a digoxin level of 0.6 …