Clinical relevance of hepatic and renal P‐gp/BCRP inhibition of drugs: An international transporter consortium perspective
… dataset was 178% for digoxin in the presence of quinidine. … amiodarone and spironolactone,
increasing digoxin AUC by … involved the inhibitor verapamil, increasing digoxin AUC by 41 …
increasing digoxin AUC by … involved the inhibitor verapamil, increasing digoxin AUC by 41 …
[PDF][PDF] Pharmacokinetic Changes and Dosage Adjustment of Digoxin in Elderly Patients with Atrial Fibrillation: A Narrative Review
M Alfaqeeh, LI Permatasari, MA Khairinisa… - Pharmacology and …, 2023 - researchgate.net
… be exercised as certain medications, such as amiodarone, diltiazem, verapamil, and quinidine,
can elevate digoxin levels in the bloodstream. Digoxin levels are used as a good toxicity …
can elevate digoxin levels in the bloodstream. Digoxin levels are used as a good toxicity …
Renal excretion of dabigatran: the potential role of multidrug and toxin extrusion (MATE) proteins
H Shen, M Yao, M Sinz, P Marathe… - Molecular …, 2019 - ACS Publications
… ([ 3 H]digoxin, 1 μM or [ 3 H]cladribine, 1 μM) was prepared in HBSS buffer containing 10 …
of 20 μM amiodarone, verapamil, clarithromycin, ketoconazole, quinidine, or pyrimethamine in …
of 20 μM amiodarone, verapamil, clarithromycin, ketoconazole, quinidine, or pyrimethamine in …
Edoxaban and the issue of drug-drug interactions: from pharmacology to clinical practice
A Corsini, N Ferri, M Proietti, G Boriani - Drugs, 2020 - Springer
… are recognised P-gp substrates [6, 55]. Indeed, verapamil, quinidine, dronedarone and
amiodarone … %, while digoxin or atorvastatin had relatively minor effects on the pharmacokinetic …
amiodarone … %, while digoxin or atorvastatin had relatively minor effects on the pharmacokinetic …
Species difference in brain penetration of P-gp and BCRP substrates among monkey, dog and mouse
Y Kido, I Nanchi, Y Fusamae, T Matsuzaki… - Drug Metabolism and …, 2022 - Elsevier
… (cetirizine, fexofenadine, verapamil, amiodarone, digoxin, quinidine and loperamide) ranged
… Prior to this study, the brain distribution of digoxin using discrete dosing in one monkey was …
… Prior to this study, the brain distribution of digoxin using discrete dosing in one monkey was …
ABCB1 and SLCO1B3 Gene Polymorphisms and Their Impact on Digoxin Pharmacokinetics in Atrial Fibrillation Patients among the Tunisian …
N Tounsi, I Trabelsi, E Kerkeni, MH Grissa, N Fredj… - Pharmacology, 2017 - karger.com
… with digoxin in AF patients such as amiodarone, propafenone and quinidine, which are P-…
In summary, our findings suggest that the inter-individual variation in SDC is not affected by …
In summary, our findings suggest that the inter-individual variation in SDC is not affected by …
Antiarrhythmic drugs: risks and benefits
P Mankad, G Kalahasty - Medical Clinics, 2019 - medical.theclinics.com
… This classification system does not include adenosine or digoxin … Because of its I To blocking
properties, quinidine has a niche … A complete discussion of the side effects of amiodarone is …
properties, quinidine has a niche … A complete discussion of the side effects of amiodarone is …
Antiarrhythmic agents and torsades de pointes
SY Wass, MK Chung - Torsades de Pointes, 2022 - Elsevier
… VA who either are not candidates for or decline an ICD, quinidine or … Oral digoxin or
amiodarone may be reasonable for ongoing … , and verapamil are ineffective or contraindicated 4 …
amiodarone may be reasonable for ongoing … , and verapamil are ineffective or contraindicated 4 …
Gut microbiota and cardiac arrhythmia: a pharmacokinetic scope
OA Nabeh - The Egyptian Heart Journal, 2022 - Springer
… ), verapamil (nor-verapamil), Quinidine (3-OH quinidine), … that the increased bioavailability
of amiodarone is due to the … P-gp transporters, digoxin level can be attenuated by GM as …
of amiodarone is due to the … P-gp transporters, digoxin level can be attenuated by GM as …
Digoxin use in cardiac amyloidosis
… He developed an episode of VT storm requiring 20 implantable cardioverter-defibrillator (ICD)
shocks in the context of also being quinidine and metronizadole with a digoxin level of 0.6 …
shocks in the context of also being quinidine and metronizadole with a digoxin level of 0.6 …