Acute hepatotoxicity of intravenous amiodarone: case report and review of the literature

CC Chen, CC Wu - American journal of therapeutics, 2016 - journals.lww.com
… Symptomatic liver injury usually associated with IV amiodarone use is rare but … IV
amiodarone-related acute hepatotoxicity in the ICU and was successfully treated by oral amiodarone

Amiodarone-induced reversible and irreversible hepatotoxicity: two case reports

T Tsuda, H Tada, Y Tanaka, N Nishida… - Journal of medical case …, 2018 - Springer
amiodarone-induced irreversible hepatotoxicity showed liver cirrhosis during treatment with
amiodarone and died of hepatic failure; the other patient, who had reversible hepatotoxicity, …

Autophagy alleviates amiodarone-induced hepatotoxicity

F Wandrer, Ž Frangež, S Liebig, K John, F Vondran… - Archives of …, 2020 - Springer
… , amiodarone-triggered toxicity was increased. In conclusion, we demonstrate that amiodarone
… keratin-18 fragment serum levels in amiodarone-treated patients. Autophagy reduces …

The role of CYP 3A4 and 1A1 in amiodarone-induced hepatocellular toxicity

Q Wu, B Ning, J Xuan, Z Ren, L Guo, MS Bryant - Toxicology letters, 2016 - Elsevier
… To study further the role of CYP1A1 and CYP3A4 in the metabolism of amiodarone, the …
amiodarone. The significant contribution of CYP1A1 and 3A4 to the hepatotoxicity of amiodarone

Acute liver failure with amiodarone infusion: A case report and systematic review

P Jaiswal, BM Attar, JE Yap, K Devani… - Journal of clinical …, 2018 - Wiley Online Library
… of oral amiodarone is thought to possibly cause hepatotoxicity … Polysorbate-80-induced
hepatotoxicity may be explained by its … perfusion19 or by its direct hepatotoxicity.20 However, the …

[HTML][HTML] Hepatic dysfunction in patients receiving intravenous amiodarone

A Hashmi, NR Keswani, S Kim… - Southern medical …, 2016 - ncbi.nlm.nih.gov
amiodarone hepatotoxicity or may actually play a role in amiodarone-induced hepatotoxicity.
… similarities in histologic features of liver ischemia and amiodarone liver injury. In our study, …

Amiodarone and risk of liver cirrhosis: a nationwide, population-based study

CH Huang, YY Lai, YJ Kuo, SC Yang… - … and Clinical Risk …, 2019 - Taylor & Francis
… Considering hepatotoxicity of amiodarone complication is usually with delayed … amiodarone
medications longer than 90 days within 1 year were eligible for inclusion in amiodarone

Establishment of a mouse model for amiodarone‐induced liver injury and analyses of its hepatotoxic mechanism

S Takai, S Oda, K Tsuneyama, T Fukami… - Journal of Applied …, 2016 - Wiley Online Library
Drug‐induced liver injury (DILI) is the most frequent cause of post‐marketing warnings and
withdrawals. Amiodarone (AMD), an antiarrhythmic, presents a risk of liver injury in humans, …

[HTML][HTML] … pharmacometabolomics based on ambient mass spectrometry imaging to evaluate the metabolism and hepatotoxicity of amiodarone in HepG2 spheroids

L Li, Q Zang, X Li, Y Zhu, S Wen, J He, R Zhang… - Journal of …, 2023 - Elsevier
… to assess the metabolism and hepatotoxicity of amiodarone (AMI). … for the mechanism of
AMI hepatotoxicity. In addition, a … viability and could characterize the hepatotoxicity of AMI. The …

[HTML][HTML] The protective effect of grape seed and Ginkgo biloba against hepatotoxicity induced by the antidysrhythmic drug “amiodarone” in male albino rats

M Abdul-Hamid, SR Galaly, H Mahmoud… - Beni-suef university …, 2018 - Elsevier
Amiodarone was an orally effective … hepatotoxicity. The actions of two antioxidants; grape
seed and Ginkgo biloba on the extent of tissue damage in amiodarone-induced hepatotoxicity