[HTML][HTML] The bench is closer to the bedside than we think: Uncovering the ethical ties between preclinical researchers in translational neuroscience and patients in …

M Yarborough, A Bredenoord, F D'Abramo… - PLoS …, 2018 - journals.plos.org
… States Food and Drug Administration (FDA) for treatment of amyotrophic lateral sclerosis (ALS), …
Is the Subject Area "Amyotrophic lateral sclerosis" applicable to this article? Yes No …

[HTML][HTML] Involvement of Lipids in the Pathogenesis of Amyotrophic Lateral Sclerosis

AV Alessenko, UA Gutner, MA Shupik - Life, 2023 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by …
when administering therapeutic drugs, such as continuous intraspinal delivery of therapeutic

A Sex-dependent Response to dl-PHPB in an Amyotrophic Lateral Sclerosis Disease Mouse Model

U MacKenzie - 2021 - dalspace.library.dal.ca
… There are currently only two FDA approved drugs for its treatment, and both offer mild …
treatment. dl-Potassium 2-(1-Hydroxypentyl)-benzoate (dlPHPB) is a novel drug for the treatment

CNS Drug Delivery in Stroke: Improving Therapeutic Translation From the Bench to the Bedside

PT Ronaldson, EI Williams, RD Betterton, JA Stanton… - Stroke, 2024 - Am Heart Assoc
… and large molecule drugs. Advancing central nervous system drug delivery technologies …
unit to be leveraged for improved bench-to-bedside translation of novel stroke therapeutics. …

Polyphenols and Stem Cells for Neuroregeneration in Parkinson's Disease and Amyotrophic Lateral Sclerosis

S Goyal, B Seth, RK Chaturvedi - Current Pharmaceutical …, 2022 - ingentaconnect.com
… stem cell therapies against the pathogenesis of PD and ALS. This review has also emphasized
different therapeutic strategies such as drug therapy, gene and immunization therapies, …

Peripheral Myelin Degeneration in Amyotrophic Lateral Sclerosis Revealed by Stimulated Raman Scattering Imaging

F Tian - 2017 - search.proquest.com
Amyotrophic lateral sclerosis (ALS) is a fast progressing … greatly promote the drug
development and the treatment of this … pre-symptomatic evaluation of ALS therapeutic, which can …

[HTML][HTML] Mitochondria, a Key Target in Amyotrophic Lateral Sclerosis Pathogenesis

EC Genin, M Abou-Ali, V Paquis-Flucklinger - Genes, 2023 - mdpi.com
… is currently no cure or even effective treatment for ALS, FTD or ALS/FTD, hence the great
interest in strategies aimed at identifying new therapeutic targets. Numerous cellular processes …

[PDF][PDF] Stem cell therapy: in treatment of neurodegenerative diseases

SK Varma, MK Hyder, S Som - J Stem Cell Res Ther, 2018 - academia.edu
… cell therapies from bench to bedside. In this review, the final … brainstem and spinal cord,
amyotrophic lateral sclerosis (ALS) … the development of conventional drug therapies difficult. The …

A basic technology-aided programme for leisure and communication of persons with advanced amyotrophic lateral sclerosis: performance and social rating

GE Lancioni, NN Singh, MF O'Reilly… - Disability and …, 2017 - Taylor & Francis
… [Citation8–12] While stem cell therapy might be one such solution in the future, present
intervention essentially relies on the use of riluzole, that is, a pharmacological aid credited with …

[HTML][HTML] Personalized medicine—Where do we stand regarding bench to bedside translation?

HRB Raghavendran, G Kumaramanickavel… - … in Medicine, 2023 - ncbi.nlm.nih.gov
amyotrophic lateral sclerosis, specific cd markers and monocyte migration in osteoarthritis
and OA synovium, and finally the significance of digital twin technology for developing precise …