miRNAs: the road from bench to bedside

G Iacomino - Genes, 2023 - mdpi.com
bench to the patient’s bedside, working on two types of drugs: antagomiRs and miRNA mimics.
The list of miRNA-based drugs in … processes in amyotrophic lateral sclerosis (ALS). In the …

A systems biology approach to understand the role of TDP-43 in amyotrophic lateral sclerosis

MRKBM Singh, U Haque, N Verma… - … Bench to Bedside, 2021 - books.google.com
… suffering from the inherited form of amyotrophic lateral sclerosis (ALS) and frontal temporal
… The drug prediction databases DGIdb was used to predict drugs that interact with the TDP-…

[PDF][PDF] Stem-cell transplantation into the frontal motor cortex in amyotrophic lateral sclerosis patients

MT González-Garza, JE Moreno-Cuevas… - academia.edu
Amyotrophic lateral sclerosis (ALS) is characterized by the selective death of motor … therapy
is considered to be an alternative treatment for ALS, as well as for cell-replacement therapy

Diabetes mellitus and amyotrophic lateral sclerosis: a systematic review

L Ferri, P Ajdinaj, MG Rispoli, C Carrarini, F Barbone… - Biomolecules, 2021 - mdpi.com
Background: Amyotrophic Lateral Sclerosis (ALS) is a degenerative disorder which affects
the motor neurons. Growing evidence suggests that ALS may impact the metabolic system, …

Development of a sensitive trial-ready poly(GP) CSF biomarker assay for C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis

E Katona, I Glaria, M Carcolé, IJ Swift, A Sogorb-Esteve… - 2022 - bura.brunel.ac.uk
… In order to progress therapies from the bench to the bedside, biomarkers of disease that …
Encouragingly, ASO treatment of mouse models has been shown to lead to durable, decreased …

[HTML][HTML] Frontal functional network disruption associated with amyotrophic lateral sclerosis: an fNIRS-based minimum spanning tree analysis

SB Borgheai, J McLinden, K Mankodiya… - Frontiers in …, 2020 - frontiersin.org
… Our findings can possibly support new bedside assessments of the functional status of ALS’
brain … patterns of the disease and lead to more efficient diagnostic and treatment methods. …

A promising new therapy for ALS

H Wood - Nature reviews. Neurology, 2021 - search.proquest.com
drug AmX0035 has beneficial effects on survival and function in people with amyotrophic
lateral sclerosis (… The two drugs individually exhibit neuroprotective properties in experimental …

Pyroptosis in neurodegenerative diseases: from bench to bedside

K Wu, W Wang, Q Cheng, H Li, W Yan, F Zhou… - Cell Biology and …, 2023 - Springer
… new therapeutic targets and updating clinical treatment strategies for … ), amyotrophic lateral
sclerosis (ALS), Parkinson’s disease (PD), Huntington’s disease (HD), and multiple sclerosis (…

Multiple sclerosis and neuroinflammation: the overview of current and prospective therapies

I Bjelobaba, D Savic, I Lavrnja - Current pharmaceutical design, 2017 - ingentaconnect.com
… motor neurons in amyotrophic lateral sclerosis (ALS) [191], in … Identifying novel drugs or
repurposing old drugs depends on our … to be brought from bench to bedside, when purinergic …

[HTML][HTML] Identification of a novel pathway in sporadic Amyotrophic Lateral Sclerosis mediated by the long non-coding RNA ZEB1-AS1

F Rey, E Maghraby, L Messa, L Esposito… - Neurobiology of …, 2023 - Elsevier
… the pathogenesis of sporadic Amyotrophic Lateral Sclerosis (sALS) is … Amyotrophic Lateral
Sclerosis (ALS) is a progressive … primary therapy for ALS with a very limited number of drugs