[HTML][HTML] Apoptosis is a demanding selective tool during the development of fetal male germ cells

I Bejarano, AB Rodríguez, JA Pariente - … in cell and developmental …, 2018 - frontiersin.org
Apoptosis orchestrates correct function and development of the male germ cell from the early
embryonic stages … We summarize that apoptosis is an essential mechanism for the suitable …

Apoptosis in the fetal testis eliminates developmentally defective germ cell clones

DH Nguyen, B Soygur, SP Peng, S Malki, G Hu… - Nature cell …, 2020 - nature.com
… our hypothesis that earlier errors in germ-cell epigenetic … that apoptosis during male germline
development functions as a … , diffusible apoptotic signals are therefore not necessary for …

Human germ cell tumours from a developmental perspective

JW Oosterhuis, LHJ Looijenga - Nature Reviews Cancer, 2019 - nature.com
… PGCs, before the first wave of demethylation, also called … factor, may have the same
function in the regulation of gene … earlier, the important role of PGCs escaping apoptosis in the …

50 years of spermatogenesis: Sertoli cells and their interactions with germ cells

MD Griswold - Biology of Reproduction, 2018 - academic.oup.com
… For the first time, it was demonstrated that germ cells can be … whether murine germ cells
required functional testosterone … and recycling” of apoptotic cells and residual bodies [70]. Clearly…

Mutations causing specific arrests in the development of mouse primordial germ cells and gonocytes

G Hamer, DG de Rooij - Biology of reproduction, 2018 - academic.oup.com
… in early mouse embryos and embryonic germ cells. While in … shown to be required for germ
cell death during later stages … functional copies of Zfp148 are required for fetal germ cells to …

p53-dependent programmed necrosis controls germ cell homeostasis during spermatogenesis

F Napoletano, B Gibert, K Yacobi-Sharon… - PLoS …, 2017 - journals.plos.org
… GC death requires an atypical function of Casp-9/Dronc … We first asked whether GC death
culminated in cellular … , A) flies and flies lacking genes required for germ cell death (BF). The …

Testicular germ cell apoptosis and spermatogenesis

B Singh, G Gupta - … Signaling in Spermatogenesis and Male …, 2019 - taylorfrancis.com
… , and its function is to maintain a pool of stem cells and to produce … Apoptosis of the germ
cell is necessary for the maintenance … An initial inhibition of germ cell apoptosis after MEHP …

Regulators in the apoptotic pathway during spermatogenesis: killers or guards?

YR Xu, HS Dong, WX Yang - Gene, 2016 - Elsevier
… the development of testis, dysfunctional GCs (germ cells) need … role in the early wave of
germ cell apoptosis. Different factors … We speculate that it has a significant function for germ cell

Actions and roles of FSH in germinative cells

K Recchia, AS Jorge, LVF Pessôa, RC Botigelli… - International Journal of …, 2021 - mdpi.com
… in the induction of germ cells and germ-cell-like cells in vitro. … germ cells, it regulates and
limits the wave of apoptosis of … for functional germ cells. They are fundamental to protecting …

Mechanisms controlling germline cyst breakdown and primordial follicle formation

C Wang, B Zhou, G Xia - Cellular and Molecular Life Sciences, 2017 - Springer
… Physiologically, functional oocytes derive from intact follicles, … First, along with the increasing
number of germ cells … which germ cell within the cyst will undergo apoptosis, or what kind of …