Aims The AARDVARK (Aortic Aneurysmal Regression of Dilation: Value of ACE-Inhibition
on RisK) trial investigated whether ACE-inhibition reduces small abdominal aortic
aneurysms (AAA) growth rate, independent of blood pressure (BP) lowering. Methods and
results A three-arm, multi-centre, single-blind, and randomized controlled trial
(ISRCTN51383267) was conducted in 14 hospitals in England. Subjects aged≥ 55 years
with AAA diameter 3.0–5.4 cm were randomized 1: 1: 1 to receive perindopril arginine 10 …

Background Although data are inconsistent, angiotensin-converting enzyme inhibitors (ACE-
Is) have been associated with a reduced incidence of abdominal aortic aneurysm (AAA)
rupture in analysis of administrative databases. Objectives (1) To investigate whether or not
the ACE-I perindopril (Coversyl arginine, Servier) reduces small AAA growth rate and (2) to
evaluate blood pressure (BP)-independent effects of perindopril on small AAA growth and to
compare the repeatability of measurement of internal and external aneurysm diameters …