Erythropoietin in the clinical trials of the cardiac disease, what is and what is not

MMM Tehrani, M Foroughi - Journal of Cellular & Molecular …, 2019 - brieflands.com
… the effects of EPO treatment in patients with MI and heart failure (… review of the cardioprotective
effects of erythropoiesis-stimulating … An updated and comprehensive meta-analysis and …

[PDF][PDF] Cardioprotective effect of erythropoietin in rats with acute myocardial infarction through JNK pathway.

GQ Li, M Chen - European Review for Medical & …, 2019 - europeanreview.org
… The present investigation explored the cardiac function indicators, the serum inflammatory
levels, and cell apoptosis, as well as the related mRNA and protein expression levels of …

Effect of Erythropoietin in patients with acute myocardial infarction: five-year results of the REVIVAL-3 trial

, … Elevation Myocardial Infarction by Erythropoietin … - BMC Cardiovascular …, 2017 - Springer
Erythropoietin mediated cardioprotective effects seem to differ across species. While
cardioprotection has been clearly shown in ischemia-reperfusion models in small rodents including …

[HTML][HTML] Are There Any Cardioprotective Effects or Safety Concerns of Erythropoietin in Patients With Myocardial Infarction? A Systematic Review

W Jean-Baptiste, AY Ali, B Inyang, FS Koshy, K George… - Cureus, 2022 - ncbi.nlm.nih.gov
… or protective value of EPO on the heart and safety concerns … Some studies were able to find
some cardioprotective impacts… any cardioprotective effect and safety concerns of EPO after …

Erythropoietin and its cardiovascular effects

N Gupta, JB Wish - Cardio-Nephrology: Confluence of the Heart and …, 2017 - Springer
… function in the ex vivo perfused heart. EPO is cardioprotective when administered at the time
… -biologic stimulation of cardiac EPO receptors during erythropoiesis stimulating agent (ESA) …

[HTML][HTML] Erythropoietin administration exerted neuroprotective effects against cardiac ischemia/reperfusion injury

T Chunchai, N Apaijai, J Benjanuwattra… - Current Research in …, 2022 - Elsevier
… Furthermore, the administration of EPO resulted in cardioprotection by stimulating PI3K/Akt
and mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) in …

Erythropoietin and its derivatives: from tissue protection to immune regulation

B Peng, G Kong, C Yang, Y Ming - Cell death & disease, 2020 - nature.com
… These small peptides prevent the cardiovascular side effects of EPO and are promising as
clinical drugs. This review briefly introduces the receptors and tissue-protective effects of EPO

Role of erythropoiesis-stimulating agents in cardiovascular protection in CKD patients: reappraisal of their impact and mechanisms

T Miura, T Sato, T Yano, A Takaguri, T Miki… - Cardiovascular Drugs …, 2023 - Springer
… factors or comorbidities were resistant to the cardioprotective effects of ESAs because of …
erythropoietin receptors. In this review, we briefly discuss basic and clinical data on the impact

[HTML][HTML] Cytoprotective effects of erythropoietin: What about the lung?

L Haine, CH Yegen, D Marchant, JP Richalet… - Biomedicine & …, 2021 - Elsevier
… , we [11] and others, showed that Epo plays a key role in neuroprotection [21], cardioprotection
[22], … effects of Epo in many organs such as brain, kidney, heart or retina and proposed …

Erythropoietin-mediated cardioprotection in hearts subjected to ischemia reperfusion

DE Vélez, VEM Cordero, R Hermann… - Journal of …, 2023 - jme.bioscientifica.com
… study was to investigate the effects of EPO on the Akt/glycogen … EPO improved the functional
recovery of the heart subjected … beneficial effects exerted by acute treatment with EPO were …