Angiotensin (1-7)-attenuated vasoconstriction is associated with the Interleukin-10 signaling pathway
RA Freitas, RRP Junior, VD Justina, AFM Bressan… - Life Sciences, 2020 - Elsevier
… Angiotensin-1-7 [Ang-(1-7)] is an essential peptide of the renin-angiotensin system that promotes
… increase in its phosphorylation and nuclear localization, while stimulation by cytokine IL…
… increase in its phosphorylation and nuclear localization, while stimulation by cytokine IL…
Angiotensin II induces differential insulin action in rat skeletal muscle
J Surapongchai, M Prasannarong… - Journal of …, 2017 - joe.bioscientifica.com
… (MAP) and heart rate (HR) were measured in conscious rats before implantation of osmotic
… of the insulin-stimulated phosphorylation of IRS-1 Ser 307 , Akt Ser 473 , AS160 Thr 642 …
… of the insulin-stimulated phosphorylation of IRS-1 Ser 307 , Akt Ser 473 , AS160 Thr 642 …
… synthetic analogue ameliorates streptozotocin-induced diabetes mellitus through modulation of ACE 2/angiotensin 1–7 via PI3K/AKT/mTOR signaling pathway
… metabolism, and we found that in normal rats the IRS-1 and IRS 2 activities were 4.20 ± 0.19
… of Ang (1–7) in stimulating the phosphorylation of JAK 2, IRS 1, and Akt in the rat heart. The …
… of Ang (1–7) in stimulating the phosphorylation of JAK 2, IRS 1, and Akt in the rat heart. The …
Angiotensin 1–7 increases cardiac tolerance to ischemia/reperfusion and mitigates adverse remodeling of the heart—The signaling mechanism
IA Derkachev, SV Popov, LN Maslov… - Fundamental & …, 2024 - Wiley Online Library
… promotes stimulation of JAK2, Akt, and PI3K in the rat myocardium [96]. These kinases …
Angiotensin-(1 7) stimulates the phosphorylation of JAK2, IRS-1 and Akt in rat heart in vivo: …
Angiotensin-(1 7) stimulates the phosphorylation of JAK2, IRS-1 and Akt in rat heart in vivo: …
The pivotal role of JAK/STAT and IRS/PI3K signaling pathways in neurodegenerative diseases: Mechanistic approaches to polyphenols and alkaloids
Background Neurodegenerative diseases (NDDs) are characterized by progressive neuronal
dysfunctionality which results in disability and human life-threatening events. In recent …
dysfunctionality which results in disability and human life-threatening events. In recent …
Insulin resistance and pellino-1 mediated decrease in the activities of vasodilator signaling contributes to sunitinib-induced hypertension
Y Liu, LL Tang, C Liang, MM Wu… - Frontiers in …, 2021 - frontiersin.org
… of IRS-1/AKT/eNOS were affected by sunitinib in rat arteries. … stimulation; bar graph represents
phospho-Tyr 612 IRS-1 … We found that phosphorylation levels of IRS-1, AKT and eNOS in …
phospho-Tyr 612 IRS-1 … We found that phosphorylation levels of IRS-1, AKT and eNOS in …
The Counteracting Effects of Ang II and Ang-(1-7) on the Function and Growth of Insulin-secreting NIT-1 Cells
X Lin, X Wang, W Feng, Y Wan, J Chai… - Current Diabetes …, 2024 - ingentaconnect.com
… Angiotensin-(1–7) stimulates the phosphorylation of JAK2, IRS-1 and Akt in rat heart in
vivo: Role of the AT 1 … Am J Physiol Heart Circ Physiol 2007; 293(2): H1154-63. http://dx.doi.org/…
vivo: Role of the AT 1 … Am J Physiol Heart Circ Physiol 2007; 293(2): H1154-63. http://dx.doi.org/…
Insight into the role of the PI3K/Akt pathway in ischemic injury and post-infarct left ventricular remodeling in normal and diabetic heart
B Walkowski, M Kleibert, M Majka, M Wojciechowska - Cells, 2022 - mdpi.com
… the insulin receptor substrate (IRS-1) and prevents its … with atorvastatin during angiotensin
2-induced oxidative stress … talk between the PI3K/Akt and JAK2/STAT3 signaling pathways, …
2-induced oxidative stress … talk between the PI3K/Akt and JAK2/STAT3 signaling pathways, …
Protective effect of angiotensin-(1-7) against hyperglycaemia-induced injury in H9c2 cardiomyoblast cells via the PI3K̸Akt signaling pathway Corrigendum in …
YY Yang, XT Sun, ZX Li, WY Chen… - international …, 2018 - spandidos-publications.com
… In the myocardium of diabetic rats, Akt phosphorylation may be … /Akt pathway promotes the
cytoprotective effect of Ang-(1-7) … ) treatment reduced inflammatory cell infiltration of the heart …
cytoprotective effect of Ang-(1-7) … ) treatment reduced inflammatory cell infiltration of the heart …
The mTOR signaling pathway in myocardial dysfunction in type 2 diabetes mellitus
… Akt can also stimulate mTORC1 kinase activity independently … lead to phosphorylation
and dampening of the function of IRS-1, an … Rapamycin selectively inhibits angiotensin II-induced …
and dampening of the function of IRS-1, an … Rapamycin selectively inhibits angiotensin II-induced …