Anti-SARS-CoV-2 IgG from severely ill COVID-19 patients promotes macrophage hyper-inflammatory responses
For yet unknown reasons, severely ill COVID-19 patients often become critically ill around
the time of activation of adaptive immunity. Here, we show that anti-Spike IgG from serum of
severely ill COVID-19 patients induces a hyper-inflammatory response by human
macrophages, which subsequently breaks pulmonary endothelial barrier integrity and
induces microvascular thrombosis. The excessive inflammatory capacity of this anti-Spike
IgG is related to glycosylation changes in the IgG Fc tail. Moreover, the hyper-inflammatory …
the time of activation of adaptive immunity. Here, we show that anti-Spike IgG from serum of
severely ill COVID-19 patients induces a hyper-inflammatory response by human
macrophages, which subsequently breaks pulmonary endothelial barrier integrity and
induces microvascular thrombosis. The excessive inflammatory capacity of this anti-Spike
IgG is related to glycosylation changes in the IgG Fc tail. Moreover, the hyper-inflammatory …
Abstract
For yet unknown reasons, severely ill COVID-19 patients often become critically ill around the time of activation of adaptive immunity. Here, we show that anti-Spike IgG from serum of severely ill COVID-19 patients induces a hyper-inflammatory response by human macrophages, which subsequently breaks pulmonary endothelial barrier integrity and induces microvascular thrombosis. The excessive inflammatory capacity of this anti-Spike IgG is related to glycosylation changes in the IgG Fc tail. Moreover, the hyper-inflammatory response induced by anti-Spike IgG can be specifically counteracted in vitro by use of the active component of fostamatinib, an FDA- and EMA-approved therapeutic small molecule inhibitor of Syk.
One sentence summary
Anti-Spike IgG promotes hyper-inflammation.
biorxiv.org
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