Anti-cancer activity of two novel heterocyclic compounds through modulation of VEGFR and miR-122 in mice bearing Ehrlich ascites carcinoma

RM Hazem, AA Mohamed, N Ghareb… - European Journal of …, 2021 - Elsevier
… component of the RAS signal transduction network. Assuming so, … upregulated on treatment
with both compounds, especially … novel anti-cancer therapeutic agents via regulating miRNA

[HTML][HTML] Phytochemicals: Current strategy to sensitize cancer cells to cisplatin

CY Sun, QY Zhang, GJ Zheng, B Feng - Biomedicine & Pharmacotherapy, 2019 - Elsevier
anti-cancer efficacy with cisplatin in colon cancer cellsmodulation of miRNA expression.
Quercetin, for example, is … Various proapoptotic signal transducers, such as MAPKs, p53, and …

Resveratrol as sensitizer in colorectal cancer plasticity

A Brockmueller, A Sajeev, L Koklesova… - Cancer and Metastasis …, 2023 - Springer
… also modulate multiple potent signaling pathways and sensitize … have been searching for
natural compounds that can be … parameters for understanding its anti-cancer effects. In this …

Targeting microRNAs with thymoquinone: a new approach for cancer therapy

M Homayoonfal, Z Asemi, B Yousefi - Cellular & Molecular Biology Letters, 2021 - Springer
… as an anti-cancer agent through modulating miRNAs. … ) and P38 MAPK are signal transduction
pathways that belong to … the cell cycle at G1 phase HCT116 colon cancer cell lines by the …

Therapeutic importance of kaempferol in the treatment of cancer through the modulation of cell signalling pathways

MY Qattan, MI Khan, SH Alharbi, AK Verma… - Molecules, 2022 - mdpi.com
anti-cancer properties of Kmp primarily occur via modulation … -3 (SOCS-3), PI3K-AKT-mTOR,
miRNA-21, signal transducer … cytotoxic effects on several colon cancerous cells such as …

Simultaneous downregulation of miR‐21 and miR‐155 through oleuropein for breast cancer prevention and therapy

M Abtin, MR Alivand, MS Khaniani… - Journal of cellular …, 2018 - Wiley Online Library
… the anti-cancer effect of oleuropein through modulation of … viability in the colon cancer
HT-29 cell line and hindered … SMAD2 An intracellular signal transducer and transcriptional …

[HTML][HTML] Regulation of multidrug resistance by microRNAs in anti-cancer therapy

X An, C Sarmiento, T Tan, H Zhu - Acta Pharmaceutica Sinica B, 2017 - Elsevier
… and alkylating compounds, which exert their action via directly … TS enzyme in colorectal
cancer cells 168 . Furthermore miR-… miRNA-127 reversed adriamycin resistance via modulating

Effects and Mechanisms of Luteolin, a Plant-Based Flavonoid, in the Prevention of Cancers via Modulation of Inflammation and Cell Signaling Molecules

SA Almatroodi, A Almatroudi, HOA Alharbi, AA Khan… - Molecules, 2024 - mdpi.com
… to outline the anti-cancer mechanisms of this compound and its … of apoptosis, in the colon
cancer cells in a dose-dependent … Signal transducer and activator of transcription 3 (STAT3) is …

Natural compounds targeting cancer-associated fibroblasts against digestive system tumor progression: therapeutic insights

KJ Chiu, HYC Chiou, CH Huang, PC Lu, HR Kuo… - Biomedicines, 2022 - mdpi.com
… CAFs modulate fibronectin deposition by integrin α5β1 in … over one-third of the recent
anti-cancer drugs are of natural … formulation also suppresses colon cancer cell proliferation by …

Dietary polyphenols suppress chronic inflammation by modulation of multiple inflammation-associated cell signaling pathways

I Jantan, MA Haque, L Arshad, H Harikrishnan… - The Journal of nutritional …, 2021 - Elsevier
… In this study, Wnt-active cells, P19 and colorectal cancer cells… has potential as an anti-cancer
candidate which significantly … cells (T98G and U138) to temozolamide through modulating