… ALK1 has been shown to play a pivotal role in regulating angiogenesis by … bone morphogenetic
protein (BMP)9 and 10. Two main pharmacological inhibitors, an ALK1-Fc fusion protein …

… Bone morphogenetic proteins (BMPs) are ligands belonging to the TGFβ superfamily. …
functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells. …

… ALK-1 is a serine/threonine kinase receptor involved in vessel maturation … anti–ALK-1
monoclonal antibody, selectively blocks binding of the ALK-1 ligands bone morphogenetic protein-…

… Activin receptor-like kinase-1 (ALK-1) is a type-I transforming growth factor (TGF)-β receptor
… Upon binding of bone morphogenetic proteins (BMP) 9 and 10, ALK-1 forms a complex with …

… of activin receptor-like kinase 1 (ALK1) plays a key role in TGF-β signaling, discovering
inhibitors of ALK1 to … related proteins, for example TGF-βs, bone morphogenetic proteins (BMPs), …

… of cytokines, the bone morphogenetic proteins (BMPs) in organ fibrosis has given contradictory
results. BMP9 is the main ligand for activin receptor-like kinase-1 (ALK1) TGF-β1 type I …

… performed siRNA knockdown of ALK1 and ALK2 and assessed … of BMP signaling using
LDN193189 attenuated Smad1/5 … ) using anti-human Eselectin-FITC, anti-human VCAM-1-PE-…

… Reduced ALK1 activity attenuates Smad 1 signaling and promotes cardiac fibrosis in heart
failure. Left, With intact … An anti-human ALK1 antibody (PF-3446962) and a ligand trap (…

… bone morphogenetic protein (BMP)9/activin receptor–like kinase (ALK)1 signaling pathway
by using an ALK1-… Anti-human Fc antibodies were purchased from R&D systems and rat anti …

… bone morphogenetic protein (BMP)9 and BMP10. Although … Based on this rationale, we
hypothesized that attenuated ALK1 … anti-human ALK1 antibody, rabbit anti-human CA1 antibody, …